期刊
ANNALS OF NEUROLOGY
卷 92, 期 3, 页码 358-363出版社
WILEY
DOI: 10.1002/ana.26429
关键词
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资金
- National Institute of Neurologic Diseases and Stroke [R01NS070834]
- National Institute on Aging (Dominantly Inherited Alzheimer's Network) [UF1AG032438, K23AG049087, P01AG036694]
- Alzheimer's Society of Canada
- National Health and Medical Research Council [APP1129627]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) [P41EB015896]
- NIH [S10RR021110, S10RR023401, S10RR023043]
This study found that white matter injury appears and progresses in D-CAA patients before the onset of cerebral microbleeds, indicating that white matter disruption measures may serve as valuable biomarkers for the progression of D-CAA.
Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022
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