期刊
ANGIOLOGY
卷 73, 期 9, 页码 818-826出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/00033197221110715
关键词
high-sensitivity C-reactive protein to albumin ratio; high-sensitivity C-reactive protein; albumin; coronary heart disease; percutaneous coronary intervention
资金
- National Key R&D Program of China [2020YFC2004700]
- National Natural Science Foundation of China [81825003, 91957123, 81800327, 81900272]
- Beijing Municipal Science & Technology Commission [Z201100006820002]
- Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases from Chinese Academy of Medical Sciences [2021RU003]
Limited studies have focused on the impact of high-sensitivity C-reactive protein to albumin ratio (CAR) on cardiovascular outcomes in patients undergoing percutaneous coronary intervention. This study found that CAR is an independent predictor of major adverse cardiovascular and cerebrovascular events (MACCE) and myocardial infarction (MI) in CHD patients undergoing drug-eluting stent implantation.
Limited studies have focused on the impact of high-sensitivity C-reactive protein (hsCRP) to albumin ratio (CAR) on cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI). Hence, the present study evaluates the association between CAR and cardiovascular outcomes in patients undergoing drug-eluting stent (DES) implantation. We consecutively enrolled 9375 CHD patients undergoing DES implantation. All patients were divided into 3 groups according to their CAR: tertile 1 (CAR <=.02, n=3125), tertile 2 (.02<=.06, n = 3125), and tertile 3 (CAR >.06, n = 3125). The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE). Kaplan-Meier analysis indicated that the incidences of MACCE and MI increased with high tertiles of the CAR (MACCE: 8.7 vs 10.5 vs 12.3%, log-rank P < .001; MI: 3.3 vs 4.0 vs 4.7%, long-rank P = .015). Cox regression analysis suggested that CAR was an independent risk factors for MACCE (HR per standard deviation (SD) increase: 1.07, 95% CI, 1.01-1.14, P = .024), and MI (HR per SD increase: 1.11, 95% CI, 1.01-1.22, P = .028). In conclusion, the CAR is an independent predictor of MACCE and MI in CHD patients.
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