4.8 Article

Carbonylative Cross-Coupling Reaction of Allylic Alcohols and Organoalanes with 1 atm CO Enabled by Nickel Catalysis

期刊

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202210484

关键词

-

资金

  1. NSFC/China [22171079]
  2. Natural Science Foundation of Shanghai [21ZR1480400]
  3. Shanghai Rising-Star Program [20QA1402300]
  4. Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
  5. Program of Introducing Talents of Discipline to Universities [B16017]
  6. Fundamental Research Funds for the Central Universities
  7. China Postdoctoral Science Foundation [2021M701197]

向作者/读者索取更多资源

A nickel-catalyzed three-component carbonylative cross-coupling reaction has been developed for the efficient synthesis of broad range of beta,gamma-unsaturated ketones at atmospheric pressure. Furthermore, the chemoselective allylic carbonylation of diols demonstrates the practicality of this method. The use of organoalanes as both coupling components and activators for alcohol functionalization is crucial, eliminating the need for extraneous activators.
A nickel-catalyzed three-component carbonylative cross-coupling reaction of allylic alcohols and organoalanes with CO at atmospheric pressure is reported, enabling the expedient formation of beta,gamma-unsaturated ketones with broad scope. Particularly, the chemoselective allylic carbonylation of diols further highlights the practicability of this protocol. The leverage of organoalanes as both the coupling components and the activators for the alcohol functionalization is crucial for this method, thus no extraneous activators are required.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据