期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 39, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202204872
关键词
Asymmetric Catalysis; Cycloadditions; Dendralenes; Domino Reactions; Hydrocarbons
资金
- Australian Research Council (ARC) Laureate Fellowship
- ARC Discovery Grants
- National Computational Infrastructure
- China Scholarship Council (CSC)
The diene-transmissive hetero-Diels-Alder sequences involving carbonyl dienophiles are reported for the first time. High enantioselectivities are achieved through the optimization of a Pd2+ catalyst system. The reaction generates fused polycyclic systems containing both heterocycles and carbocycles.
Diene-transmissive hetero-Diels-Alder sequences involving carbonyl dienophiles are reported for the first time. High enantioselectivities are achieved in the reaction of phenylglyoxal with a broad range of dendralene structures, through the optimization of a Pd2+ catalyst system. The initial catalyst-controlled enantioselective oxa-Diels-Alder (ODA) cycloaddition to a [3]dendralene generates a dihydropyran carrying a semicyclic diene. This participates in a subsequent catalyst or substrate-controlled Diels-Alder reaction to generate sp(3)-rich fused polycyclic systems containing both heterocycles and carbocycles. Computational investigations reveal a concerted asynchronous mechanism. pi-Complexation of a diene C=C bond to Pd2+ occurs in both the pre-transition state (TS) complex and in cycloaddition TSs, controlling stereoselectivity. A formal enantioselective [4+2]cycloaddition of a CO2 dienophile is demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据