A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.

Automated summary

After more than 20 years of trials, a practical scalable method for synthesizing fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of F-BCPs were studied, and the core structure was successfully incorporated into the synthesis of the anti-inflammatory drug Flurbiprofen.