期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 29, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202205103
关键词
Bicyclo[1; 1; 0]butane; Bicyclo[1; 1; 1]pentane; Bioisosteres; Fluorine
资金
- European Research Council (ERC) under the European Union [101000893-BENOVELTY]
After more than 20 years of trials, a practical scalable method for synthesizing fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of F-BCPs were studied, and the core structure was successfully incorporated into the synthesis of the anti-inflammatory drug Flurbiprofen.
After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据