Synchronous electrochemical detection of dopamine and uric acid by a PMo12@MIL-100(Fe)@PVP nanocomposite

In this work, a noble-metal-free composite electrode was prepared based on PMo12O403-(PMo12), C9H5FeO7-(MIL-100(Fe), a Fe-based metal organic framework) and polyvinylpyrrolidone (PVP), and served as a high performance electrochemical sensor for synchronous detection of dopamine (DA) and uric acid (UA). The PMo12@MIL-100(Fe)@PVP composite electrode was fabricated by a in-situ hydrothermal method. Thanks to the synergistic effect of three active components (PMo12, MIL-100 and PVP), the electrode possesses large specific surface area and high electrical conductivity and therefore it shows high electrocatalytic oxidation performance of DA and UA with a spacing of 0.146 V between the two peak positions. These benefits of the electrode enable its electrochemical sensor to synchronously detect of DA and UA. Namely, the linear ranges can achieve 1-247 mu M for DA and 5-406 mu M for UA. Meanwhile, the detection limits are 0.586 mu M for DA and 0.372 mu M for UA. Moreover, the sensor can be applied to simultaneous determination of UA and DA in human serums with satisfactory recovery values.

Automated summary

A high-performance electrochemical sensor for synchronous detection of dopamine and uric acid has been successfully developed using a noble-metal-free composite electrode. The electrode exhibits large specific surface area and high electrical conductivity, leading to high electrocatalytic oxidation performance of dopamine and uric acid.