4.5 Article

40 Years of Pfs48/45 Research as a Transmission-Blocking Vaccine Target of Plasmodium falciparum Malaria

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

A Reproducible and Scalable Process for Manufacturing a Pfs48/45 Based Plasmodium falciparum Transmission-Blocking Vaccine

Susheel K. Singh et al.

Summary: This study presents a scalable and reproducible process for manufacturing R0.6C under cGMP, resulting in a sufficient yield for clinical evaluation. Various analytical assays were established to assess the identity, release, and stability of R0.6C, confirming its potential for use as a malaria transmission-blocking vaccine. Preclinical studies demonstrated that R0.6C elicited functional antibodies and showed enhanced response when combined with adjuvant.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Preclinical development of a Pfs230-Pfs48/45 chimeric malaria transmission-blocking vaccine

Susheel K. Singh et al.

Summary: The modified construct ProC6C successfully improved expression levels, paving the way for further clinical evaluation. A scalable process in the Lactococcus lactis expression system was developed, along with a panel of analytical assays for release and stability. Immunogenicity studies in mice demonstrated that ProC6C can induce functional antibodies that reduce transmission to mosquitoes and invasion of human hepatocytes.

NPJ VACCINES (2021)

Review Immunology

Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes

Roos M. de Jong et al.

Summary: This study investigated the impact of natural genetic diversity on the functional activity of transmission-blocking antibodies. Despite the conserved nature of sexual stage antigens, minor sequence variation can significantly impact the efficacy of transmission-blocking antibodies. The findings support further clinical development of mAb 45.1 and may inform Pfs48/45 vaccine design.

NPJ VACCINES (2021)

Review Immunology

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

Roos M. de Jong et al.

IMMUNOLOGICAL REVIEWS (2020)

Article Multidisciplinary Sciences

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

Will J. R. Stone et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

Frank Lennartz et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Structural delineation of potent transmission- blocking epitope I on malaria antigen Pfs48/45

Prasun Kundu et al.

NATURE COMMUNICATIONS (2018)

Review Immunology

The GMZ2 malaria vaccine: from concept to efficacy in humans

Michael Theisen et al.

EXPERT REVIEW OF VACCINES (2017)

Review Immunology

Towards clinical development of a Pfs48/45-based transmission blocking malaria vaccine

Michael Theisen et al.

EXPERT REVIEW OF VACCINES (2017)

Article Public, Environmental & Occupational Health

Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens

Jonathan J. Juliano et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2016)

Review Parasitology

Naturally acquired immunity to sexual stage P. falciparum parasites

Will J. R. Stone et al.

PARASITOLOGY (2016)

Article Multidisciplinary Sciences

Structure of the Plasmodium 6-cysteine s48/45 domain

Silvia A. Arredondo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Correctly folded MUM protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

Nikolay S. Outchkourov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Epitope analysis of the malaria surface antigen Pfs48/45 identifies a subdomain that elicits transmission blocking antibodies

Nikolay Outchkourov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Medicine, Research & Experimental

Sexual-stage antibody responses to P-falciparum in endemic populations

JT Bousema et al.

CURRENT MOLECULAR MEDICINE (2006)

Article Multidisciplinary Sciences

Structural models for the protein family characterized by gamete surface protein Pfs230 of Plasmodium falciparum

DL Gerloff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)