☆ 4.6 Editorial Material

Alveolar Repair after Viral Injury: A Tale of Two Cell Types

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2022)

Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection

Belinda J. Hernandez et al.

Summary: AT1 cells play an important role in lung injury-repair, persisting in AT2 cell-depleted areas and upregulating immune response genes while receding from invading airway cells.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2022)

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Article Cell & Tissue Engineering

Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration

Ian J. Penkala et al.

Summary: The regeneration of the architecturally complex alveolar niche of the lung requires precise temporal and spatial control of epithelial cell behavior. Injury can result in a permanent reduction in gas exchange surface area and respiratory function. The plasticity of alveolar type 1 cells plays a crucial role in driving regeneration, particularly in the early postnatal period.

CELL STEM CELL (2021)

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Article Medicine, Research & Experimental

Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease

Kangyun Wu et al.

Summary: The study identified an imbalance of basal epithelial cell growth and differentiation in postviral lung disease, leading to the expansion of a cell subset connected to IL-33 and chromatin accessibility, resulting in long-term bronchiolar-alveolar remodeling. Disruption of Il33 gene function in basal epithelial cells disrupted epithelial barrier homeostasis and attenuated disease progression in the lung by downregulating remodeling and inflammation. These findings provide new insights for stratifying and treating chronic postviral diseases.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Pathology