期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 88, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/aji.13610
关键词
CD8(+) T cells; decidual tissue; hepatitis B virus; placenta; term pregnancy
资金
- National Natural Science Foundation of China [82022007]
- Nanfang Hospital, Southern Medical University [2020J003]
- Guangdong Provincial Pearl River Talents Program [2017BT01S131]
This study found that the function of decidual CD8(+) T cells is compromised in term pregnant women with chronic HBV infection, supporting the necessity and importance of antiviral intervention in preventing mother-to-child transmission of HBV.
Problem Hepatitis B virus (HBV) infection is more likely to develop a state of chronicity in early life, particularly mother-to-child transmission (MTCT) of HBV in the fetus during pregnancy. Till now, little is known about the impact of chronic HBV infection on the immune status of the maternal-fetus interface, and the immune profile of placental lymphocytes in MTCT of HBV is poorly understood. Method of Study Thirteen term pregnant women with chronic HBV infection (HBV-PW) and thirteen normal pregnant women as healthy control (HC-PW) were enrolled. The profile of placental immune cells and paired peripheral blood were analyzed by flow cytometry and immunohistochemistry. Results Compared with HC-PW, the frequency of CD8(+) T cells from the term placenta of HBV-PW was significantly reduced. These cells showed decreased expression of activation molecules CD69 and HLA-DR; thus, decidual CD8(+) T cells from HBV-PW demonstrated hypofunctional signature as evidenced by significantly reduced production of IFN-gamma, as well as compromised ability of degranulation and proliferation. Conclusions These findings supported that hypoactivated decidual CD8(+) T cells might possess compromised ability in chronically HBV-infected term pregnant women. Our study provides robust evidence for the necessity and importance of antiviral intervention in HBV-PW to prevent MTCT of HBV.
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