Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage

Review Peripheral Vascular Disease

Aldosterone, Inflammation, Immune System, and Hypertension

Nathanne S. Ferreira et al.

Summary: Excess aldosterone is associated with cardiovascular and metabolic diseases, as it activates immune cells and leads to organ damage. Studies have shown that aldosterone activates various subsets of innate and adaptive immune cells, pointing towards potential new biomarkers and therapeutic targets for diseases associated with elevated aldosterone levels.

AMERICAN JOURNAL OF HYPERTENSION (2021)

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Review Cardiac & Cardiovascular Systems

Role of interleukin-23/interleukin-17 axis in T-cell-mediated actions in hypertension

Akinori Higaki et al.

Summary: Hypertension is partially mediated by immune mechanisms, with IL-23 and IL-17 playing important roles. The IL-23/IL-17 axis has not been a major therapeutic target for hypertension treatment, but shows potential for targeting therapy.

CARDIOVASCULAR RESEARCH (2021)

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Review Cell Biology

Immune mechanisms in arterial hypertension. Recent advances

Ulrich O. Wenzel et al.

Summary: This article highlights the role of inflammation in hypertension and hypertensive end-organ damage, noting that immune cells from both the innate and adaptive immune systems are involved. It also discusses the impact of sodium intake on immune cell function and the potential benefits of modulating the immune response to reduce the severity of hypertension and end-organ damage.

CELL AND TISSUE RESEARCH (2021)

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Article Pharmacology & Pharmacy

Nonsteroidal mineralocorticoid receptor antagonism for cardiovascular and renal disorders - New perspectives for combination therapy

Peter Kolkhof et al.

Summary: Over the past 30 years, there has been significant progress in understanding the role of aldosterone and mineralocorticoid receptor in cardiovascular and kidney diseases. Ongoing research is focused on developing safer and more effective nonsteroidal MR antagonists.

PHARMACOLOGICAL RESEARCH (2021)

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Review Cell Biology

Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved

Beatriz Delgado-Valero et al.

Summary: Cardiorenal syndrome describes the complex interaction between heart and kidney disease, with renal dysfunction posing a significant threat to cardiac patients. Fibrosis is a key factor in the progression of organ injury and is believed to play a crucial role in the pathophysiology of cardiorenal syndromes.

CELLS (2021)

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Review Immunology

γδ T cells in tissue physiology and surveillance

Julie C. Ribot et al.

Summary: γδT cells, a unique subpopulation of T cells, are rare in secondary lymphoid organs but play key roles in immune responses and tissue homeostasis, with exciting new studies demonstrating their diverse physiological functions in tissues.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy