More Evidence Links Microglia and Neuroinflammation With Hypertension

Article Peripheral Vascular Disease

Blockade of Microglial Activation in Hypothalamic Paraventricular Nucleus Improves High Salt-Induced Hypertension

Xiao-Jing Yu et al.

Summary: This study demonstrates that high salt intake leads to microglial activation in the hypothalamic paraventricular nucleus, resulting in the release of proinflammatory cytokines and oxidative stress. These processes contribute to sympathetic overactivity and the development of hypertension. Inhibiting microglial activation can attenuate inflammation and oxidative stress, thereby reducing the development of high salt-induced hypertension.

AMERICAN JOURNAL OF HYPERTENSION (2022)

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Review Physiology

Immunity and Hypertension

Rong M. Zhang et al.

Summary: Studies have shown that immune cell infiltration and chronic inflammation play a critical role in the development of hypertension and its complications. Depletion of immune cells can improve endothelial function, reduce oxidative stress, lower vascular tone, and prevent kidney damage, indicating potential novel antihypertensive therapies through understanding immune cell functioning.

ACTA PHYSIOLOGICA (2021)

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Article Immunology

PLIN2 Mediates Neuroinflammation and Oxidative/Nitrosative Stress via Downregulating Phosphatidylethanolamine in the Rostral Ventrolateral Medulla of Stressed Hypertensive Rats

Shutian Zhang et al.

Summary: Oxidative/nitrosative stress and neuroinflammation play crucial roles in hypertension by mediating sympathetic overactivation. Regulating microglia and lipid composition can effectively alleviate the pathophysiological processes of stress-induced hypertension.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Optogenetic activation of spinal microglia triggers chronic pain in mice

Min-Hee Yi et al.

Summary: The study demonstrated that optogenetic activation of spinal microglia induced chronic pain hypersensitivity through increased neuronal activity via IL-1 signaling pathway.

PLOS BIOLOGY (2021)

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Article Immunology