4.6 Article

Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron-deficient mouse pregnancies

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Summary: The hormone erythroferrone (ERFE) is produced by erythroid cells to release iron for erythropoiesis by suppressing hepcidin production. Overexpression of ERFE can lead to iron overload, impaired hepatic signaling, and hepcidin deficiency. Neutralizing excessive ERFE in anemias can prevent iron overload and potentially benefit growth and development.
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