4.5 Letter

Author's Reply to Pestana et al. Comment on: Is There a Role for Therapeutic Drug Monitoring in Patients with Hidradenitis Suppurativa on Tumor Necrosis Factor-α Inhibitors?

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Dermal tunnels influence time to clinical response and family history influences time to loss of clinical response in patients with hidradenitis suppurativa treated with adalimumab

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Summary: The presence of dermal tunnels significantly influences the odds of achieving HiSCR and the time to achieve HiSCR, while family history influences time to loss of HiSCR.

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Therapeutic Drug Monitoring in Patients with Suboptimal Response to Adalimumab for Hidradenitis Suppurativa: A Retrospective Case Series

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Summary: This study examined serum adalimumab concentrations and anti-adalimumab antibody status in 38 patients with moderate-to-severe hidradenitis suppurativa who had suboptimal response to adalimumab therapy. The results showed that patients with anti-adalimumab antibodies had significantly lower adalimumab levels, suggesting that therapeutic drug monitoring may help identify reasons for suboptimal response and guide dose optimization strategies.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

Article Gastroenterology & Hepatology

Higher Postinduction Infliximab Concentrations Are Associated With Improved Clinical Outcomes in Fistulizing Crohn's Disease: An ACCENT-II Post Hoc Analysis

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Summary: This study found that higher post-induction infliximab concentrations are associated with early and long-term favorable therapeutic outcomes in patients with fistulizing Crohn's disease.

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