期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 38, 期 10, 页码 817-821出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2022.0067
关键词
HIV-1; CRF68_01B; CRF01_AE; subtype A1
资金
- Key Science and Technology Planning Project of Hebei province [192777107D]
Homosexual contact has become the most frequent route of HIV-1 transmission in Hebei, China. A new second-generation recombinant form of HIV-1, originating from CRF68_01B and CRF01_AE, has been identified among men who have sex with men (MSM). This finding highlights the importance of monitoring HIV-1 diversity and implementing effective measures to control viral recombination in Hebei province.
In recent years, homosexual contact has been the most frequent route of human immunodeficiency virus type one (HIV-1) transmission in Hebei, China. The number of circulating recombinant forms (CRFs) and unique recombinant forms found in this key population were more and more. In this study, we identified a novel HIV-1 second-generation recombinant form originated from CRF68_01B and CRF01_AE among men who have sex with men (MSM) through the phylogenetic and recombinant breakpoints analyses based on the near full-length genome. Both CRF68_01B and CRF01_AE were circulating in the Hebei province of China, and this MSM was diagnosed as the recent HIV-1 infection in fact. The result reminds that we should constantly monitor HIV-1 diversity in Hebei and take further effective to control the recombination of not only HIV-1 major strains but also minor strains.
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