Low-Voltage-Driven Electrochemical Aerobic Oxygenation with Flavin Catalysis: Chemoselective Synthesis of Sulfoxides from Sulfides

The chemoselective electrochemical oxygenation of sulfides to sulfoxides is performed using a biomimetic flavin catalyst that enables the activation of molecular oxygen under a low cathode potential. Diverse functional groups, including alcohols, ketones, aldehydes, cyclopropane, carboxylic acids, pyridine, alkenes, and alkynes, are well tolerated under low-voltage electrolytic conditions.

Automated summary

The chemoselective electrochemical oxygenation of sulfides to sulfoxides is achieved using a biomimetic flavin catalyst that activates molecular oxygen under low cathode potential. Various functional groups are well tolerated under low-voltage electrolytic conditions.