Radical C-H Alkylation with Ethers and Unactivated Cycloalkanes toward the Assembly of Tetrasubstituted Amino Acid Derivatives

A radical alpha-C-H alkylation of a collection of N-picolinamide amino acid derivatives with ethers and cycloalkanes as chemical feedstock is described. This cross-dehydrogenative coupling is distinguished by its reliable scalability and removable auxiliary group, and enables the assembly of a variety of tri- and tetrasubstituted amino acid compounds.

Automated summary

This study describes a radical alpha-C-H alkylation of a collection of N-picolinamide amino acid derivatives using ethers and cycloalkanes as chemical feedstock. This method is characterized by its reliable scalability and removable auxiliary group, and allows for the assembly of various tri- and tetrasubstituted amino acid compounds.