期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 364, 期 17, 页码 2989-2995出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202200437
关键词
Arylacetaldehydes; Aryl aldehydes or Diaryl ketones; DMSO; KOH; One-Carbon Extension
资金
- National Natural Science Foundation of China [21572049]
A one-step protocol is developed for the synthesis of arylacetaldehydes from aryl aldehydes or diaryl ketones, providing a potential efficient method for organic synthesis.
A one-step protocol is described for the synthesis of arylacetaldehydes from aryl aldehydes or diaryl ketones by using the system of DMSO/KOH/zinc. In this transformation, DMSO provides a methine fragment that converts the -CHO structure in aryl aldehydes or the -CO- structure in diaryl ketones to the -CH2CHO structure in arylacetaldehydes via a one-carbon extension. This protocol could also be used to synthesize arylacetaldehyde acetals from aryl aldehydes or diaryl ketones when zinc was replaced by diols. In this protocol, 25 examples of arylacetaldehydes and 26 examples of arylacetaldehyde acetals have been synthesized from aryl aldehydes or diaryl ketones. Based on control experiments and the literature, a plausible reaction mechanism is proposed in our work.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据