期刊
ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 36, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202205690
关键词
metal-phenolic networks; radiotherapy; sonodynamic therapy; tumor hypoxic microenvironment; ultrasound
类别
资金
- National Natural Science Foundation of China [NSFC 32171318]
- Faculty of Health Sciences, University of Macau
- Science and Technology Development Fund, Macau SAR [0109/2018/A3, 0011/2019/AKP, 0113/2019/A2, 0103/2021/A, 0002/2021/AKP]
- Shenzhen Science and Technology Innovation Commission
- Shenzhen-Hong Kong-Macau Science and Technology Plan C [SGDX20201103093600004]
- Proteomics, Metabolomics, and Drug Development Core in the Faculty of Health Sciences, University of Macau
- Animal Research Core in the Faculty of Health Sciences, University of Macau
- Biological Imaging and Stem Cell Core in the Faculty of Health Sciences, University of Macau
This study proposes a two-step strategy to alleviate tumor hypoxia and enhance tumor radiotherapy using physical stimulation and nanoparticles. The results show that this strategy effectively inhibits tumor growth and activates immune response.
The tumor hypoxic microenvironment is a dynamic status that is closely related to tumor growth, metastasis, clearance, and recurrence. Hypoxic conditions are present in almost all tumors, which greatly reduce the clinical effects of tumor therapy. Considering the physical tolerance and dose-related side effects of clinical cancer radiotherapy (RT) patients, herein, a universal two-step strategy is designed based on safe, noninvasive, deep penetration, and intensity-controlled ultrasound method to alleviate hypoxia and enhance tumor RT. The first step is to alleviate the tumor hypoxia by physical stimulation from noninvasive and controllable low-intensity pulsed ultrasound (LIPUS). In the second step, based on the use of polyethylene glycol (PEG) polymer, PEG-polyphenols are applied to encapsulate radiosensitizers platinum (Pt) and assembled with sonosensitizers PEG-purpurin 18 (PEG-P18) into nanoparticles (NPs) as PP18-Pt NPs with good biocompatibility and pharmacokinetic properties in combination with RT and sonodynamic therapy to achieve a high level of reactive oxygen species-mediated tumor oxidative stress. The results show that LIPUS is a safe modality to effectively modulate hypoxia levels. The two-step strategy based on PP18-Pt NPs can effectively inhibit the growth of breast cancer tumors and activate the body's antitumor immune response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据