期刊
ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 38, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202205802
关键词
disinfector-assisted reduction; melanoma; photothermal treatment; reduced graphene oxide-protein; surgical dressing
类别
资金
- ERC Starting Grant (STROFUNSCAFF)
- Medical Research Council (UK Regenerative Medicine Platform Acellular/Smart Materials 3D Architecture) [MR/R015651/1]
- AO Foundation [AOCMF17-19M]
- Spanish Government [PID2019-110709RB-100, RED2018-102417-T]
- Junta de Castilla y Leon [VA317P18, Infrared2018-UVA06]
- Interreg V Espana Portugal POCTEP [0624_2IQBIONEURO_6_E]
- Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Leon
A disinfectant-assisted low temperature method to reduce GO-protein materials and fabricate surgical dressings with tuneable photothermal efficiency and bioactive properties for the postoperative treatment of melanoma is reported. In vitro and in vivo validation revealed the capacity of the dressings to prevent tumor recurrence and promote healing after tumor resection.
Materials that combine the functionalities of both of proteins and graphene are of great interest for the engineering of biosensing, drug delivery, and regenerative devices. Graphene oxide (GO) offers an opportunity to design GO-protein interactions but the need for harsh reduction processes to enable GO photoexcitation remains a limitation. A disinfector-assisted low temperature method to reduce GO-protein materials and fabricate surgical dressings with tuneable photothermal efficiency and bioactive properties for the postoperative treatment of melanoma is reported. The approach harnesses the capacity of 70% ethanol to penetrate the protein shell of microorganisms to infiltrate GO-protein complexes and reduce GO at low temperature (85 degrees C) while maintaining the material structure and bioactivity. Both experiments and coarse-grained simulations are used to describe the reduction process and assess the material properties. In vitro and in vivo validation revealed the capacity of the dressings to prevent tumor recurrence and promote healing after tumor resection.
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