期刊
ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 36, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202205371
关键词
aggregation-induced emissions; immunosuppression reversal; NIR-II imaging; pancreatic cancer; photo-immunotherapy
类别
资金
- National Natural Science Foundation of China [82171990, 52122317, 22175120]
- Hainan Province Key Area RD Program [ZDYF2021SHFZ094]
- Developmental Fund for Science and Technology of Shenzhen government [RCYX20200714114525101, JCYJ20190808153415062]
- Natural Science Foundation for Distinguished Young Scholars of Guangdong Province [2020B1515020011]
A 980 nm absorbing agent, TPE-BT-BBTD, was developed for the treatment of advanced deep-seated tumors. The agent possesses deep near-infrared-II fluorescence imaging (NIR-II FLI) functionality and outstanding photothermal performance, making it suitable for advanced pancreatic cancer treatment. With the attachment of alpha PD-L1 antibody, alpha PD-L1@TPE-BT-BBTD nanoparticles demonstrate precise tumor targeting and excellent immunosuppression reversal ability. By inducing immunogenic tumor vaccination and enhancing cytotoxic T lymphocytes (CTLs) activity, the nanoparticles effectively suppress tumor growth and metastases.
To address urgent tasks in the treatment of advanced deep-seated tumors, a 980 nm absorbing agent with aggregation-induced emission tendency, namely TPE-BT-BBTD, which simultaneously possesses the longest absorption wavelength among all the reported AIE molecules is developed. The functionality of deep near-infrared-II fluorescence imaging (NIR-II FLI) and outstanding photothermal performance is well-tailored for advanced pancreatic cancer treatment. With the covalent attachment of the programmed death-ligand 1 (alpha PD-L1) antibody, alpha PD-L1@TPE-BT-BBTD nanoparticles show precise tumor targeting and excellent immunosuppression reversal ability. Following local photothermal therapy, immunogenic tumor vaccination is induced to trigger the infiltration of cytotoxic T lymphocytes (CTLs) in tumors. With the decreased FoxP3(+) Treg cells and M2-like macrophages that are reversed by alpha PD-L1, CTLs activity is further enhanced with more production of granzyme B (GrB), which much accurately leads to tumor apoptosis and effectively suppressed spontaneous metastases. Overall, alpha PD-L1@TPE-BT-BBTD nanoparticles based NIR-II FLI-mediated photo-immunotherapy is able to significantly improve the control of primary tumor and metastasis in the treatment of advanced deep-seated tumors.
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