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Natural Polymer-Derived Bioscaffolds for Peripheral Nerve Regeneration

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Conductive Nerve Guidance Conduits Based on Morpho Butterfly Wings for Peripheral Nerve Repair

Yangnan Hu et al.

Summary: Inspired by the structures of peripheral nerves, researchers have developed a conductive topological scaffold for nerve repair using modified butterfly wings. The scaffold showed increased neurite length and guided cellular orientation, and successfully repaired nerve defects in rats.

ACS NANO (2022)

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Article Engineering, Biomedical

Development of a regenerative porous PLCL nerve guidance conduit with swellable hydrogel-based microgrooved surface pattern via 3D printing

Hyun Su Lee et al.

Summary: Peripheral nerve injury leads to loss of motor and sensory functions, increasing morbidity. Autogenous nerve grafts are the current gold standard for reconstruction, but have limitations due to limited donor supply. This study developed a PLCL/gelatin conduit as a promising alternative, demonstrating successful axonal regeneration and functional recovery. This research offers a potential substitute for autogenous nerve grafts.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Environmental

A dual-drug enhanced injectable hydrogel incorporated with neural stem cells for combination therapy in spinal cord injury

Zhiping Qi et al.

Summary: This study developed a dual-drug enhanced injectable hydrogel combined with neural stem cells to promote tissue regeneration and reduce glial scar formation in a rat complete transected SCI model. The hydrogel showed improved proliferation and neuronal differentiation in vitro, leading to enhanced neuronal integration and inhibited glial scar formation in vivo. Overall, the dual-drug enhanced hydrogel holds promise for combination therapy in SCI treatment.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Multidisciplinary

Sustainable release of nerve growth factor for peripheral nerve regeneration using nerve conduits laden with Bioconjugated hyaluronic acid-chitosan hydrogel

Haixing Xu et al.

Summary: The study investigates the repair of injured peripheral nerves in rats using PDLLA/beta-TCP nerve conduits laden with CS-HA/NGF hydrogels, showing that the hydrogels promote adhesion, spreading, and differentiation of neuronal cells while sustaining NGF release. In vivo studies demonstrate a significant positive effect on axon regeneration and myelination compared to control groups, indicating the potential of CS-HA/NGF injectable hydrogel in promoting nerve regeneration in neural tissue engineering.

COMPOSITES PART B-ENGINEERING (2022)

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Article Biochemistry & Molecular Biology

Biocompatible Polyurethane Conduit Grafted with Vascular Endothelial Growth Factor-Loaded Hydrogel Repairs the Peripheral Nerve Defect in Rats

Wanlin Xu et al.

Summary: The study created a PU/Gel/VEGF conduit which promotes proliferation, migration, and expression of neural markers in nerve cells, aiding in functional recovery of the injured side.

MACROMOLECULAR BIOSCIENCE (2022)

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Review Chemistry, Multidisciplinary

3D Printed Personalized Nerve Guide Conduits for Precision Repair of Peripheral Nerve Defects

Kai Liu et al.

Summary: Nerve autograft is currently the preferred treatment for peripheral nerve defects but has limitations. Emerging nerve guide conduits (NGCs), especially those made through 3D printing, offer effective platforms for repairing peripheral nerve defects.

ADVANCED SCIENCE (2022)

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Article Multidisciplinary Sciences

Bio-inspired shape-memory structural color hydrogel film

Yu Wang et al.

Summary: Inspired by the color adjusting mechanism of hummingbird, researchers have developed a shape-memory hydrogel film with structural colors. The film exhibits excellent flexibility and stable stretchability, and possesses shape-morphing behaviors capability. By integrating photothermal responsive graphene quantum dots, the film also shows light-controlled reversible deformation with synchronous structural color variation. This shape-memory structural color hydrogel film holds great potential for applications in soft robotics.

SCIENCE BULLETIN (2022)

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Article Engineering, Biomedical

Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function

Hongcai Yang et al.

Summary: Polyurethane (PU) NGCs modified by different weight ratio of Gastrodin were designed for sequential and sustainable drug release, creating a favorable microenvironment for nerve regeneration. The scaffold showed suitable pore structure and biocompatibility in vitro, and promoted morphological and functional recovery of regenerated sciatic nerves in vivo.

BIOACTIVE MATERIALS (2022)

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Review Anatomy & Morphology

Polysaccharides, as biological macromolecule-based scaffolding biomaterials in cornea tissue engineering: A review

Qiwei Dong et al.

Summary: Artificial cornea implants have become the gold standard for treating damaged corneas, but face challenges such as donor shortage and graft failure; polysaccharides such as cellulose, chitosan are widely used in the production of tissue-engineered corneas, and have excellent biocompatibility and processability.

TISSUE & CELL (2022)

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Article Materials Science, Multidisciplinary

Natural proteins-derived asymmetric porous conduit for peripheral nerve regeneration

Hui Zhang et al.

Summary: A novel silk fibroin-derived nerve guidance conduit (NGC) with internal-facing inverse opal structures is developed for local neurotrophic factor delivery and effective nerve regeneration. The NGC demonstrates excellent biocompatibility, suitable biodegradability, and spatial control over the distribution of loading factors, leading to enhanced therapeutic efficacy.

APPLIED MATERIALS TODAY (2022)

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Article Engineering, Biomedical

Implantable nerve guidance conduits: Material combinations, multi-functional strategies and advanced engineering innovations

Yixin Yan et al.

Summary: This review comprehensively summarizes the importance and progress of nerve guidance conduits (NGCs) in clinical applications. The study found that combining natural and synthetic materials with advanced manufacturing technologies can improve the performance and compatibility of NGCs. Furthermore, challenges and future opportunities in the field of NGCs were discussed.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

Lin Jin et al.

Summary: This study developed a band-aid with a core-shell structure to modulate vascularization and the immune microenvironment, leading to scarless wound healing. The band-aid released H2S and a growth factor, which controlled macrophage polarization and inhibited excessive inflammation, thereby promoting skin cell proliferation and facilitating wound healing.

BIOACTIVE MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Cellulose-Based Flexible Functional Materials for Emerging Intelligent Electronics

Dawei Zhao et al.

Summary: Cellulose, as a natural biopolymer, has advantages such as low cost, renewability, easy processability, and appealing mechanical performance, dielectricity, piezoelectricity. These make it a key material for flexible electronic devices and have significant impact on portable intelligent electronics.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Fabrication and in vitro evaluation of 3D composite scaffold based on collagen/hyaluronic acid sponge and electrospun polycaprolactone nanofibers for peripheral nerve regeneration

Elahe Entekhabi et al.

Summary: The study successfully fabricated a tissue engineered nerve graft composed of electrospun PCL conduit filled with COL-HA sponge, which showed good mechanical properties and biocompatibility, providing a permissive environment for Schwann cell proliferation and maturation as well as promoting axon growth in rat sciatic nerve.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Review Engineering, Biomedical

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Fabio Rizzo et al.

Summary: Injectable hydrogels are of great interest in the biomedical field for their potential in controlled and localized drug delivery while limiting nonspecific drug distribution in healthy tissues. Stimuli-responsive injectable hydrogels have been designed to change shape or volume in response to environmental stimuli, ensuring optimal drug delivery to target sites.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Instruments & Instrumentation

Improving sciatic nerve regeneration by using alginate/chitosan hydrogel containing berberine

Majid Rahmati et al.

Summary: Peripheral nerve injuries caused by trauma can lead to pain and disability in patients. Berberine, with its various properties, can be used to enhance peripheral nerve injuries. The study demonstrated the positive effect of berberine-containing alginate/chitosan hydrogel on the regeneration of the sciatic nerve, indicating its potential therapeutic value in treating peripheral nerve injuries.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Ice-Inspired Lubricated Drug Delivery Particles from Microfluidic Electrospray for Osteoarthritis Treatment

Lei Yang et al.

Summary: Particle-based drug delivery systems show significant value in osteoarthritis treatment. By developing functional particles with enhanced lubrication and therapeutic effects through microfluidic electrospray, potential applications in clinical settings are promising. This approach offers precise control over particle size, chemical modification, and drug loading, showcasing great potential for improved treatment outcomes.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Cellulose-Based Hybrid Aerogels: Strategies toward Design and Functionality

Vahid Rahmanian et al.

Summary: Early aerogels from inorganic precursors led to the discovery of organic counterparts, with cellulose aerogels standing out due to their abundance, biocompatibility, and tunable properties. Despite inherent limitations, recent advancements in cellulose-based hybrid aerogels show promise in overcoming these drawbacks and improving functionality. Collaboration between organic and inorganic components in these hybrid aerogels enhances their performance and opens up new possibilities for future development and applications.

ADVANCED MATERIALS (2021)

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Multifunctional Composite Inverse Opal Film with Multiactives for Wound Healing

Wanqing Weng et al.

Summary: The multiactive encapsulated inverse opal film shows a potent antibacterial effect and promotes angiogenesis by loading vascular endothelial growth factor into nanopores and encapsulating by chitosan, making it crucial in chronic wound healing. The color change of the film structure can intuitively reflect the drug release progress, serving as a real-time drug monitoring system. In the affected wound model, the film's properties in promoting wound healing are confirmed by faster healing speed, more granulation tissue, less inflammation, and the distribution of new blood vessels and collagen, demonstrating its practical application value in clinical wound care.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Aligned Graphene Mesh-Supported Double Network Natural Hydrogel Conduit Loaded with Netrin-1 for Peripheral Nerve Regeneration

Qun Huang et al.

Summary: In this study, a graphene mesh-supported double-network hydrogel scaffold loaded with netrin-1 was engineered to promote peripheral nerve regeneration and improve surgical outcomes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Nerve guidance conduit promoted peripheral nerve regeneration in rats

Qingshan Long et al.

Summary: Heparin-crosslinked collagen nerve guidance conduits successfully delivered NGF and promoted nerve regeneration at the site of facial nerve defect in rats. The conduits enhanced axonal growth and Schwann cell proliferation, with similar nerve regeneration and functional recovery outcomes as autologous nerve grafting. The nerve guidance conduit may provide a safer approach for nerve regeneration.

ARTIFICIAL ORGANS (2021)

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Review Chemistry, Multidisciplinary

Natural Biopolymer-Based Biocompatible Conductors for Stretchable Bioelectronics

Chunya Wang et al.

Summary: This review focuses on recent advances in biocompatible conductors based on natural biopolymers for stretchable bioelectronics, including representative biopolymers such as protein, polypeptide, and polysaccharide. The review summarizes the chemical structure and properties of these biopolymers, discusses their interface with electronic components and biological tissue, as well as various fabrication techniques and applications.

CHEMICAL REVIEWS (2021)

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Review Biotechnology & Applied Microbiology

Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications

Gitishree Das et al.

Summary: This review discusses the recent innovations in SER-based nano-medicines and their potential applications in biomedicine, especially in areas such as anti-tumor, antimicrobials, and antioxidants. The different molecular mechanisms for promoting therapeutic applications are considered.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

Mina Keshvardoostchokami et al.

Summary: Research on various types of polymer nanofibers as artificial extracellular matrices has shown controllable physiochemical properties, enabling the engineering of microenvironments to support cell function through functionalization. The nanofibrous scaffolds were categorized into five main groups, and their role in supporting cellular function was discussed.

NANOMATERIALS (2021)

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Review Materials Science, Multidisciplinary

Collagen- and hyaluronic acid-based hydrogels and their biomedical applications

Qinghua Xu et al.

Summary: Hydrogels based on collagen and hyaluronic acid have been extensively studied for their potential biomedical applications due to their similarities with the extracellular matrix. These hydrogels can mimic the structure and function of ECM, showing promise for commercialization in various biomedical fields.

MATERIALS SCIENCE & ENGINEERING R-REPORTS (2021)

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Article Materials Science, Multidisciplinary

Functional nanomaterials in peripheral nerve regeneration: Scaffold design, chemical principles and microenvironmental remodeling

Yun Qian et al.

Summary: The imbalance of neuronal microenvironment is crucial in the process of neural regeneration. Traditional neural-supporting scaffolds lack biomimetic nanotechnology designs and modifications, making them unsatisfactory. Nanomaterial-based scaffolds show better regenerative effects with enhanced biochemical and physicochemical properties.

MATERIALS TODAY (2021)

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Article Cell Biology

Basic fibroblast growth factor accelerates myelin debris clearance through activating autophagy to facilitate early peripheral nerve regeneration

Yongsheng Jiang et al.

Summary: Recent studies indicate that the therapeutic effect of bFGF on nerve regeneration may be closely related to accelerating the autophagic clearance of myelin debris during WD, leading to an enhanced phagocytic capacity of Schwann cells to engulf myelin debris.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Polymer Science

Collagen blended with natural polymers: Recent advances and trends

Alina Sionkowska

Summary: This review provides a report on recent advances in the field of research on collagen blends with other natural polymers, discussing the potential applications of such blends in the biomedical field and cosmetic preparations.

PROGRESS IN POLYMER SCIENCE (2021)

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Review Polymer Science

Natural and synthetic polymeric scaffolds used in peripheral nerve tissue engineering: Advantages and disadvantages

Shahram Amini et al.

Summary: The nervous system, composed of nerves and cells, is vital for the body but can be damaged by various causes. Nerve tissue engineering is a promising method for repairing damaged nerve tissues, utilizing a combination of natural and synthetic polymers to promote regeneration.

POLYMERS FOR ADVANCED TECHNOLOGIES (2021)

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Article Chemistry, Multidisciplinary

Antigen-Presenting Hybrid Colloidal Crystal Clusters for Promoting T cells Expansion

Xin Shou et al.

Summary: In this study, artificial antigen-presenting scaffolds were developed for ex vivo expansion of T cells, which effectively promoted T cell expansion with robust antitumor activity through internal encapsulation of prosurvival cytokines and surface activation antibodies. The antigen-presenting HCCCs provide a novel platform for clinical manufacturing of T cells.

SMALL (2021)

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Article Chemistry, Multidisciplinary

DNA-Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo-Controlled Osteoarthritis Gene Therapy

Zhijie Chen et al.

Summary: Gene therapy is a powerful strategy to overcome the limitations of traditional therapeutics, but faces challenges in dosage form, delivery method, and application value. In this study, interference oligonucleotides integrated with gold nanorods were used to fabricate spherical nucleic acids (SNAs) for regulating gene expression related to cartilage inflammation. The constructed system showed improved stability and efficiency in cell internalization, with promising results in down-regulating catabolic proteases and up-regulating anabolic components in cartilage.

ADVANCED SCIENCE (2021)

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Article Engineering, Biomedical

Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries

Lihua Luo et al.

Summary: By optimizing the scaffold material synthesis protocol, a third-generation nerve regeneration conduit CSM-GFD was constructed and applied for repairing a 15-mm long defect of the sciatic nerve in a rat model. At histologic and physical levels, the conduit regenerated nerve tissue and achieved functional recovery, showing promising potential as a tissue engineering approach for treating large gap defects in peripheral nerve injuries.

BIOACTIVE MATERIALS (2021)

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Article Polymer Science

Anisotropic Silk-Inspired Nerve Conduit with Peptides Improved the Microenvironment for Long-Distance Peripheral Nerve Regeneration

Xiaoxuan Tang et al.

Summary: A silk-inspired phototriggered gelation system was developed to improve peripheral nerve regeneration, combining anisotropic topography and adhesive ligands for enhanced cell recruitment and axon growth. This multifunctional bioactive system provides significant nerve regeneration with function recovery for long-distance nerve injury, delivering a platform for desirable peripheral nerve repair.

ACS MACRO LETTERS (2021)

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Article Nanoscience & Nanotechnology

Protein-Based Hybrid Responsive Microparticles for Wound Healing

Hui Zhang et al.

Summary: The development of controllable responsive microparticles composed of natural polymer materials, loaded with growth factors and antibacterial peptides, shows promising potential for drug release and wound healing applications. Under near-infrared (NIR) irradiation, these microparticles can achieve desired controllable release of growth factors to promote neovascularization formation. Additionally, the antibacterial peptides embedded in the microparticles provide antibacterial ability during storage and usage. These characteristics make the microparticles ideal for drug delivery and wound healing.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Emerging Functional Biomaterials as Medical Patches

Yu Wang et al.

Summary: Medical patches have been widely explored and applied in various medical fields, achieving great success as multifunctional medical devices. They are used in wound healing, tissue engineering, drug delivery, and real-time health monitoring, attracting extensive attention and research interest. Challenges and prospects for the future development of medical patches are also discussed in research.

ACS NANO (2021)

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Review Pharmacology & Pharmacy

Supramolecular engineering of hydrogels for drug delivery

Stephane Bernhard et al.

Summary: Supramolecular binding motifs are increasingly utilized in the design of biomaterials, particularly in drug delivery systems. Rational engineering of specific associations enables injectable or sprayable hydrogels, achieving minimally invasive administration in drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Magnetic Assembly of a Multifunctional Guidance Conduit for Peripheral Nerve Repair

Merav Antman-Passig et al.

Summary: Nerve growth conduits play a crucial role in supporting and promoting axon regeneration following nerve injuries. A biomimetic regenerative gel enriched with magnetic nanoparticles coated with nerve growth factor has been developed, showing promising effects on enhancing nerve regeneration in in vivo rat models. The magnet-based therapeutic conduits demonstrate oriented and directed axonal growth, providing a novel therapeutic approach to overcoming current medical obstacles for nerve injuries.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Physical

State-of-the-art of 3D printing technology of alginate-based hydrogels-An emerging technique for industrial applications

Shadpour Mallakpour et al.

Summary: Three-dimensional (3D) printing technology has gained unprecedented attention in various fields due to its numerous advantages, with alginate, a versatile polysaccharide derived from seaweed, being widely used for its excellent printability and biocompatibility in the field of 3D printed biomaterials.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Article Engineering, Biomedical

Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration

Xianhao Dong et al.

Summary: Research on nerve conduits composed of oriented microfiber-bundle cores and randomly organized nanofiber sheaths has shed light on the regulatory role of microfiber orientation in promoting peripheral nerve regeneration, elucidating a cascade of biological responses and ultimately enhancing nerve regeneration outcomes.

BIOMATERIALS (2021)

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Article Chemistry, Applied

TPP ionically cross-linked chitosan/PLGA microspheres for the delivery of NGF for peripheral nerve system repair

Wen Zeng et al.

Summary: NGF-loaded chitosan/PLGA composite microspheres ionically cross-linked by tripolyphosphate (TPP/Chitosan/PLGA-NGF) were successfully prepared to control NGF release in injured peripheral nerves. Analysis of encapsulation efficiency, size, stability, and release rate confirmed the effectiveness of TPP/Chitosan/PLGA-NGF microspheres for neural tissue repair in both in vitro and in vivo experiments.

CARBOHYDRATE POLYMERS (2021)

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Article Materials Science, Multidisciplinary

Injectable biomimetic shellfish macromolecule conductive microcarriers loaded with adipose-derived stem cells for nerve repair in vivo

Mengjiao Ma et al.

Summary: Filling conductive guiding cues into nerve conduits, using self-polymerized dopamine to prepare conductive microcarriers, has shown promising results in promoting nerve defect repair and demonstrating good potential in vivo.

APPLIED MATERIALS TODAY (2021)

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Article Engineering, Biomedical

Chinese herb microneedle patch for wound healing

Junjie Chi et al.

Summary: The study introduces a novel Chinese herb microneedle patch, which promotes wound healing and has various medicinal effects such as heat clearing, detoxicating, and antibacterial properties. By integrating pure herbal compositions with advanced technologies, the research demonstrates the potential development and promotion of traditional Chinese medicine in modern society.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Polylysine-decorated macroporous microcarriers laden with adipose-derived stem cells promote nerve regeneration in vivo

Yi Sun et al.

Summary: Cell transplantation using microcarriers is an effective strategy to improve nerve regeneration and repair outcomes, presenting a new therapeutic approach for peripheral nerve repair.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair

Ping Wu et al.

Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.

BIOACTIVE MATERIALS (2021)

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Review Engineering, Biomedical

Biomaterials from the sea: Future building blocks for biomedical applications

Mei-chen Wan et al.

Summary: Marine resources hold great potential for developing high-value biomaterials, with materials such as chitin, marine-derived collagen, and more showcasing excellent biocompatibility, biodegradability, and bioactive characteristics. These marine biomaterials find important applications in medical, antimicrobial, drug delivery, rehabilitation, and industrial areas.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats

Can Liu et al.

Summary: Conductive scaffolds have shown therapeutic effects for patients with peripheral nerve injuries. The development of biocompatible electroconductive hydrogels has been proposed in this study, which can promote nerve repair and functional recovery.

BIOACTIVE MATERIALS (2021)

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Review Polymer Science

Gelatin-Based Nanocomposites: A Review

Zhi Yang et al.

Summary: This manuscript summarizes extensive research and new advancements on gelatin and gelatin-based nanocomposites, as well as their important applications in various scientific fields. Gelatin-based nanocomposites have superior physico-chemical properties compared to gelatin alone.

POLYMER REVIEWS (2021)

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Article Engineering, Biomedical

Zn-MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Shun Yao et al.

Summary: A degradable zinc-MOF encapsulated microneedles array was fabricated in this study, showing excellent antibacterial activity and biocompatibility, which can accelerate wound healing and tissue regeneration.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

Niranjan G. Kotla et al.

Summary: Hyaluronan, a naturally occurring biopolymer, has diverse biological effects and plays a crucial role in inflammation and cancer. This review discusses the sources, properties, and potential applications of hyaluronan in therapeutic systems and cancer targeting delivery.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Cell & Tissue Engineering

Biomimetic nerve guidance conduit containing engineered exosomes of adipose-derived stem cells promotes peripheral nerve regeneration

Zheng Yang et al.

Summary: In this study, engineered exosomes were used as carriers to efficiently deliver NT-3 mRNA to recipient cells and promote nerve regeneration in a rat sciatic nerve defect model, demonstrating the potential for improving nerve regeneration.

STEM CELL RESEARCH & THERAPY (2021)

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Review Engineering, Biomedical

Extracellular Matrix-Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin-Like Polypeptide Hydrogels

Derek W. Nelson et al.

Summary: ECM-mimetic hydrogels are promising regenerative scaffolds for injured nervous system, providing 3D bioactive interfaces to modulate cellular response and support tissue remodeling. Future advancements in their design and use may lead to viable treatments for patients with neural injury.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Multidisciplinary Sciences

Bionic microenvironment-inspired synergistic effect of anisotropic micro-nanocomposite topology and biology cues on peripheral nerve regeneration

Guicai Li et al.

Summary: This study constructed a bionic microenvironment-inspired scaffold integrated with anisotropic micro-nanocomposite topographies and IKVAV peptide, showing effective induction of orientation growth of Schwann cells and up-regulation of genes and proteins relevant to myelination. Three main signal pathways were proposed, revealing the synergistic effects of anisotropic micro-nanocomposite topographies and biological cues on neuroregeneration. This study provides an important strategy for developing functional artificial nerve implants.

SCIENCE ADVANCES (2021)

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Article Materials Science, Multidisciplinary

Injectable, antioxidative, and neurotrophic factor-deliverable hydrogel for peripheral nerve regeneration and neuropathic pain relief

Yunfan Kong et al.

Summary: The study developed a multifunctional hydrogel for repairing acute peripheral nerve injury, which showed effectiveness in improving sensorimotor function, preventing muscular atrophy, protecting neurons, promoting nerve regeneration and remyelination. The hydrogel also alleviated PNI-induced pain by reversing pain-related changes, but supplementing with GDNF may interrupt the recovery process and counteract the pain alleviation effect. Further research on the therapeutic effect of GDNF in PNI treatment is needed.

APPLIED MATERIALS TODAY (2021)

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Article Engineering, Biomedical

Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment

Ohan S. Manoukian et al.

Summary: The study investigates novel nerve guidance conduits with aligned microchannel porosity delivering sustained-release of neurogenic 4-aminopyridine for peripheral nerve regeneration. Results show equivalency with autograft controls in terms of functional recovery, myelin development, and histological assessments. The aligned microchannel architecture of the conduit guides axons and the sustained release of 4-AP increases nerve conduction.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Stretchable and Conductive Composite Structural Color Hydrogel Films as Bionic Electronic Skins

Hui Zhang et al.

Summary: The authors proposed a novel composite structural color hydrogel film for constructing ideal multiple-signal bionic electronic skins, showing obvious color variation and electromechanical properties for real-time color sensing and electrical response. This new material widens the practical value of bionic electronic skins.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Xinyi Gu et al.

Summary: The pure silk fibroin hydrogel with high strength and aligned microgrooved structure showed excellent mechanical properties and good biocompatibility. The aligned microgrooved structure enabled the aligned growth of Schwann cells, promoting axon growth and guiding neurite sprouting. This micropatterned SF hydrogel has great potential for peripheral nerve regeneration.

NANOTECHNOLOGY REVIEWS (2021)

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Article Engineering, Biomedical

Engineering Silk Fibroin-Based Nerve Conduit with Neurotrophic Factors for Proximal Protection after Peripheral Nerve Injury

Cristiana R. Carvalho et al.

Summary: Artificial nerve conduits made of silk fibroin are developed to incorporate neurotrophic factors for effective nerve regeneration. The controlled delivery of nerve growth factor and GDNF in these conduits is demonstrated to promote retrograde neuroprotection and motor nerve reinnervation, showing significant improvement in nerve regeneration after injury.

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Review Chemistry, Multidisciplinary

Colloidal Crystals from Microfluidics

Feika Bian et al.

SMALL (2020)

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Article Multidisciplinary Sciences

Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment

Hui Zhang et al.

SCIENCE BULLETIN (2020)

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Review Engineering, Biomedical

Silk biomaterials in wound healing and skin regeneration therapeutics: From bench to bedside

Dimple Chouhan et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

3D-engineered GelMA conduit filled with ECM promotes regeneration of peripheral nerve

Hui Gong et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Review Chemistry, Multidisciplinary

Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration

Ohan S. Manoukian et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Cell Biology

Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates

Neil B. Fadia et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Chemistry, Multidisciplinary

Functional Polymer-Based Nerve Guide Conduits to Promote Peripheral Nerve Regeneration

Xi Zhang et al.

ADVANCED MATERIALS INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Multichannel Nerve Guidance Conduit Based on Shape Memory Nanofibers for Potential Application in Peripheral Nerve Repair

Jing Wang et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

3D-Printed Nerve Conduits with Live Platelets for Effective Peripheral Nerve Repair

Jie Tao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Electrically Conductive Hydrogel Nerve Guidance Conduits for Peripheral Nerve Regeneration

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ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Materials Science, Multidisciplinary

Responsive drug -delivery microcarriers based on the silk fibroin inverse opal scaffolds for controllable drug release

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APPLIED MATERIALS TODAY (2020)

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Article Engineering, Biomedical

Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing

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BIOACTIVE MATERIALS (2020)

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Fabrication of 3D Scaffolds Displaying Biochemical Gradients along Longitudinally Oriented Microchannels for Neural Tissue Engineering

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ACS APPLIED MATERIALS & INTERFACES (2020)

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Controlling the Release of Neurotrophin-3 and Chondroitinase ABC Enhances the Efficacy of Nerve Guidance Conduits

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ADVANCED HEALTHCARE MATERIALS (2020)

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Review Clinical Neurology

Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective

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Poultry gelatin: Characteristics, developments, challenges, and future outlooks as a sustainable alternative for mammalian gelatin

Ahmadreza Abedinia et al.

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Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

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NATURE COMMUNICATIONS (2020)

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Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing

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A 3D-Printed Self-Adhesive Bandage with Drug Release for Peripheral Nerve Repair

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Keratin - Based materials for biomedical applications

Sandleen Feroz et al.

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Agarose degradation for utilization: Enzymes, pathways, metabolic engineering methods and products

Chengcheng Jiang et al.

BIOTECHNOLOGY ADVANCES (2020)

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Adjustable conduits for guided peripheral nerve regeneration prepared from bi-zonal unidirectional and multidirectional laminar scaffold of type I collagen

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Materials Science & Engineering C-Materials for Biological Applications (2020)

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Mechanical, topographical and chemical cues combined with physical therapy for peripheral nerve injuries

Tonya J. Whitehead et al.

REGENERATIVE MEDICINE (2020)

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Augmented peripheral nerve regeneration through elastic nerve guidance conduits prepared using a porous PLCL membrane with a 3D printed collagen hydrogel

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Differentiation of bMSCs on Biocompatible, Biodegradable, and Biomimetic Scaffolds for Largely Defected Tissue Repair

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ACS APPLIED BIO MATERIALS (2020)

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Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats

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THERANOSTICS (2020)

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Scaffolds for peripheral nerve repair and reconstruction

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EXPERIMENTAL NEUROLOGY (2019)

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PAM/GO/gel/SA composite hydrogel conduit with bioactivity for repairing peripheral nerve injury

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Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery

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Sericin Nerve Guidance Conduit Delivering Therapeutically Repurposed Clobetasol for Functional and Structural Regeneration of Transected Peripheral Nerves

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Local delivery of FK506 to injured peripheral nerve enhances axon regeneration after surgical nerve repair in rats

Kasra Tajdaran et al.

ACTA BIOMATERIALIA (2019)

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Review Neurosciences

Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery

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FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization

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NATURE COMMUNICATIONS (2019)

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Multilayered spraying and gradient dotting of nanodiamond-polycaprolactone guidance channels for restoration of immune homeostasis

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NPG ASIA MATERIALS (2019)

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Review Engineering, Biomedical

Natural Polymer-Based Hydrogels with Enhanced Mechanical Performances: Preparation, Structure, and Property

Ziting Bao et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Adaptable Microporous Hydrogels of Propagating NGF-Gradient by Injectable Building Blocks for Accelerated Axonal Outgrowth

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ADVANCED SCIENCE (2019)

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Hyaluronan as tunable drug delivery system

Alberto Passi et al.

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Advanced Collagen-Based Biomaterials for Regenerative Biomedicine

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The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met

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FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Spinning and Applications of Bioinspired Fiber Systems

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Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair

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ACTA BIOMATERIALIA (2019)

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Gelatin-polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Samson Afewerki et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2019)

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The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Anna Sorushanova et al.

ADVANCED MATERIALS (2019)

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Combining growth factor releasing microspheres within aligned nanofibers enhances neurite outgrowth

Tonya J. Whitehead et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

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Article Engineering, Biomedical

Sustained delivery of glial cell-derived neurotrophic factors in collagen conduits for facial nerve regeneration

Fukai Ma et al.

ACTA BIOMATERIALIA (2018)

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Review Pharmacology & Pharmacy

In situ forming injectable hydrogels for drug delivery and wound repair

Robert Dimatteo et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Biomedical Applications of Recombinant Silk-Based Materials

Tamara Bernadette Aigner et al.

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Cellulose-Based Biomimetics and Their Applications

Ana P. C. Almeida et al.

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Engineering the Future of Silk Materials through Advanced Manufacturing

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ADVANCED MATERIALS (2018)

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Article Engineering, Biomedical

Heparin-Poloxamer Thermosensitive Hydrogel Loaded with bFGF and NGF Enhances Peripheral Nerve Regeneration in Diabetic Rats

Rui Li et al.

BIOMATERIALS (2018)

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Optimal electrical stimulation boosts stem cell therapy in nerve regeneration

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BIOMATERIALS (2018)

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Review Biochemical Research Methods

Strategic Design and Fabrication of Nerve Guidance Conduits for Peripheral Nerve Regeneration

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BIOTECHNOLOGY JOURNAL (2018)

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Article Chemistry, Applied

Spatially featured porous chitosan conduits with micropatterned inner wall and seamless sidewall for bridging peripheral nerve regeneration

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CARBOHYDRATE POLYMERS (2018)

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Constructing conductive conduit with conductive fibrous infilling for peripheral nerve regeneration

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CHEMICAL ENGINEERING JOURNAL (2018)

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Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design

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COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration

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NATURE COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Anisotropic architecture and electrical stimulation enhance neuron cell behaviour on a tough graphene embedded PVA: alginate fibrous scaffold

Nasim Golafshan et al.

RSC ADVANCES (2018)

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Review Biochemical Research Methods

Strategic Design and Fabrication of Nerve Guidance Conduits for Peripheral Nerve Regeneration

Md Sarker et al.

BIOTECHNOLOGY JOURNAL (2018)

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Review Chemistry, Multidisciplinary

Polysaccharide-Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside

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Article Chemistry, Multidisciplinary

Multifunctional Chitosan Inverse Opal Particles for Wound Healing

Canwen Chen et al.

ACS NANO (2018)

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Review Engineering, Biomedical

Bioactive Silk-Based Nerve Guidance Conduits for Augmenting Peripheral Nerve Repair

Adrian Magaz et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Review Chemistry, Multidisciplinary

Design, Fabrication, and Function of Silk-Based Nanomaterials

Yu Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Engineering, Biomedical

Silk Fibroin Microparticles with Hollow Mesoporous Silica Nanocarriers Encapsulation for Abdominal Wall Repair

Xin Zhao et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Review Cell Biology

Current and novel polymeric biomaterials for neural tissue engineering

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JOURNAL OF BIOMEDICAL SCIENCE (2018)

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A Dual-Layered Microfluidic System for Long-Term Controlled In Situ Delivery of Multiple Anti-Inflammatory Factors for Chronic Neural Applications

Laura Frey et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Review Biochemistry & Molecular Biology

Oxidized Alginate-Based Hydrogels for Tissue Engineering Applications: A Review

Supachai Reakasame et al.

BIOMACROMOLECULES (2018)

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Article Chemistry, Multidisciplinary

Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration

Xiaoming Sun et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Review Materials Science, Multidisciplinary

Prospects of peripheral nerve tissue engineering using nerve guide conduits based on silk fibroin protein and other biopolymers

Mehdi Farokhi et al.

INTERNATIONAL MATERIALS REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis

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INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

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Review Biochemistry & Molecular Biology

Role of Netrin-1 Signaling in Nerve Regeneration

Xin-Peng Dun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Nanoscience & Nanotechnology

A review of fibrin and fibrin composites for bone tissue engineering

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Review Pharmacology & Pharmacy

Chitosan oligosaccharide: Biological activities and potential therapeutic applications

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PHARMACOLOGY & THERAPEUTICS (2017)

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Magnetic Nanoparticles for Efficient Delivery of Growth Factors: Stimulation of Peripheral Nerve Regeneration

Martina Giannaccini et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Engineering, Biomedical

A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair

Alan J. Ryan et al.

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Article Cell & Tissue Engineering

Gelatin-based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering

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JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

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Development and characterization of cores-shell poly(lactide-co-glycolide)-chitosan microparticles for sustained release of GDNF

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COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Nanoscience & Nanotechnology

Multichanneled Nerve Guidance Conduit with Spatial Gradients of Neurotrophic Factors and Oriented Nanotopography for Repairing the Peripheral Nervous System

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Repairing sciatic nerve injury with an EPO-loaded nerve conduit and sandwiched-in strategy of transplanting mesenchymal stem cells

Wei Zhang et al.

BIOMATERIALS (2017)

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Review Chemistry, Applied

Alginate microparticles as oral colon drug delivery device: A review

Lissette Aguero et al.

CARBOHYDRATE POLYMERS (2017)

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Chitosan degradation products facilitate peripheral nerve regeneration by improving macrophage-constructed microenvironments

Yahong Zhao et al.

BIOMATERIALS (2017)

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A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer-Directed Cell Recruitment

Xiaoxia Hu et al.

ADVANCED MATERIALS (2017)

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Article Engineering, Biomedical

Neural stem/progenitor cells on collagen with anchored basic fibroblast growth factor as potential natural nerve conduits for facial nerve regeneration

Fukai Ma et al.

ACTA BIOMATERIALIA (2017)

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Article Engineering, Biomedical

An engineered biocompatible drug delivery system enhances nerve regeneration after delayed repair

Kasra Tajdaran et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2016)

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Review Engineering, Biomedical

Silk protein-based hydrogels: Promising advanced materials for biomedical applications

Sonia Kapoor et al.

ACTA BIOMATERIALIA (2016)

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Article Medicine, Research & Experimental

4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury

Kuang-Ching Tseng et al.

EMBO MOLECULAR MEDICINE (2016)

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Article Chemistry, Multidisciplinary

Multifunctional natural agarose as an alternative material for high-performance rechargeable lithium-ion batteries

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GREEN CHEMISTRY (2016)

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Review Chemistry, Analytical

Agarose- and alginate-based biopolymers for sample preparation: Excellent green extraction tools for this century

Mohd Marsin Sanagi et al.

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Article Polymer Science

Cellulose-Based Gels

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MACROMOLECULAR CHEMISTRY AND PHYSICS (2016)

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Review Materials Science, Multidisciplinary

Keratin: Structure, mechanical properties, occurrence in biological organisms, and efforts at bioinspiration

Bin Wang et al.

PROGRESS IN MATERIALS SCIENCE (2016)

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Review Polymer Science

Interests of chitosan nanoparticles conically cross-linked with tripolyphosphate for biomedical applications

Loic Bugnicourt et al.

PROGRESS IN POLYMER SCIENCE (2016)

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Article Cell Biology

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Fuqin Fan et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Article Cell & Tissue Engineering

Facial nerve regeneration using basic fibroblast growth factor-impregnated gelatin microspheres in a rat model

Hajime Matsumine et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2016)

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Article Neurosciences

Chitosan Degradation Products Promote Nerve Regeneration by Stimulating Schwann Cell Proliferation via miR-27a/FOXO1 Axis

Yongjun Wang et al.

MOLECULAR NEUROBIOLOGY (2016)

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Article Multidisciplinary Sciences

3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration

Yu Hu et al.

SCIENTIFIC REPORTS (2016)

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Article Biotechnology & Applied Microbiology

A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506)

Kasra Tajdaran et al.

BIOTECHNOLOGY AND BIOENGINEERING (2015)

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Review Biochemistry & Molecular Biology

Fibrin matrices: The versatile therapeutic delivery systems

Ejaj Ahmad et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Review Polymer Science

Structures, mechanical properties and applications of silk fibroin materials

Leng-Duei Koh et al.

PROGRESS IN POLYMER SCIENCE (2015)

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Review Materials Science, Multidisciplinary

Application of natural and semi-synthetic polymers for the delivery of sensitive drugs

O. Germershaus et al.

INTERNATIONAL MATERIALS REVIEWS (2015)

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Article Engineering, Biomedical

Self-crosslinked oxidized alginate/gelatin hydrogel as injectable, adhesive biomimetic scaffolds for cartilage regeneration

Biji Balakrishnan et al.

ACTA BIOMATERIALIA (2014)

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Article Engineering, Biomedical

Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs

Yi Cui et al.

BIOMATERIALS (2014)

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Article Engineering, Biomedical

Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system

Mikinori Ikeda et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

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Review Chemistry, Multidisciplinary

Fibrin as a delivery system in wound healing tissue engineering applications

D. Whelan et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Neurosciences

Peripheral Nerve Injury Modulates Neurotrophin Signaling in the Peripheral and Central Nervous System

Mette Richner et al.

MOLECULAR NEUROBIOLOGY (2014)

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Article Multidisciplinary Sciences

Incorporation of Chitosan Microspheres into Collagen-Chitosan Scaffolds for the Controlled Release of Nerve Growth Factor

Wen Zeng et al.

PLOS ONE (2014)

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Review Engineering, Biomedical

Biomaterial-based drug delivery systems for the controlled release of neurotrophic factors

Nima Khadem Mohtaram et al.

BIOMEDICAL MATERIALS (2013)

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Article Biotechnology & Applied Microbiology

Self-cross-linkable hydrogels composed of partially oxidized alginate and gelatin for myocardial infarction repair

Xiuping Bai et al.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2013)

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Review Surgery

Nerve Repair by Means of Tubulization: Past, Present, Future

P. Konofaos et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2013)

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Review Neurosciences

Neurotrophin regulation of neural circuit development and function

Hyungju Park et al.

NATURE REVIEWS NEUROSCIENCE (2013)

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Article Engineering, Biomedical

Injectable systems and implantable conduits for peripheral nerve repair

Yen-Chih Lin et al.

BIOMEDICAL MATERIALS (2012)

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Review Chemistry, Multidisciplinary

Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications

Yulin Li et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Review Chemistry, Multidisciplinary

Growth factor delivery systems and repair strategies for damaged peripheral nerves

Srinivas Madduri et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Article Clinical Neurology

Efficacy of Short-Term FK506 Administration on Accelerating Nerve Regeneration

Ying Yan et al.

NEUROREHABILITATION AND NEURAL REPAIR (2012)

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Article Engineering, Biomedical

Peripheral nerve regeneration using a microporous polylactic acid asymmetric conduit in a rabbit long-gap sciatic nerve transection model

Shan-hui Hsu et al.

BIOMATERIALS (2011)

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Article Pharmacology & Pharmacy

Ionically cross-linked chitosan microspheres for controlled release of bioactive nerve growth factor

Wen Zeng et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Article Clinical Neurology

Enhancement of sciatic nerve regeneration after vascular endothelial growth factor (VEGF) gene therapy

F. R. Pereira Lopes et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)

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Review Pharmacology & Pharmacy

Targeted delivery of low molecular drugs using chitosan and its derivatives

Jae Hyung Park et al.

ADVANCED DRUG DELIVERY REVIEWS (2010)

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Article Engineering, Biomedical

Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration

S. Madduri et al.

BIOMATERIALS (2010)

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Article Engineering, Biomedical

Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit

Li Yao et al.

BIOMATERIALS (2010)

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Article Engineering, Biomedical

Ciliary neurotrophic factor-coated polylactic-polyglycolic acid chitosan nerve conduit promotes peripheral nerve regeneration in canine tibial nerve defect repair

Hua Shen et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2010)

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Article Chemistry, Multidisciplinary

Fibrin glue as a drug delivery system

Patrick P. Spicer et al.

JOURNAL OF CONTROLLED RELEASE (2010)

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Article Materials Science, Multidisciplinary

Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications

R. Jayakumar et al.

PROGRESS IN MATERIALS SCIENCE (2010)

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Article Engineering, Biomedical

Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps

Mahesh Chandra Dodla et al.

BIOMATERIALS (2008)

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Review Chemistry, Multidisciplinary

Injectable hydrogels as unique biomedical materials

Lin Yu et al.

CHEMICAL SOCIETY REVIEWS (2008)

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Article Engineering, Biomedical

Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration

Yumin Yang et al.

BIOMATERIALS (2007)

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Article Engineering, Biomedical

Silk fibroin matrices for the controlled release of nerve growth factor (NGF)

Lorenz Uebersax et al.

BIOMATERIALS (2007)

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Article Engineering, Biomedical

Hydrogel nerve conduits produced from alginate/chitosan complexes

Lukas A. Pfister et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2007)

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Article Neurosciences

Effects of local continuous release of brain derived neurotrophic factor (BDNF) on peripheral nerve regeneration in a rat model

E. Voegelin et al.

EXPERIMENTAL NEUROLOGY (2006)

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Article Chemistry, Multidisciplinary

Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release

A Goraltchouk et al.

JOURNAL OF CONTROLLED RELEASE (2006)

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Article Engineering, Biomedical

Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds

B Balakrishnan et al.

BIOMATERIALS (2005)

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Article Endocrinology & Metabolism

Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats

AP Mizisin et al.

DIABETES (2004)

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Article Neurosciences

FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers

E Udina et al.

EXPERIMENTAL NEUROLOGY (2003)

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Article Neurosciences

FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation

OAR Sulaiman et al.

EXPERIMENTAL NEUROLOGY (2002)

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