期刊
ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 41, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202205662
关键词
bacterial cellulose; cartilages; hydrogels; implants; polyvinyl alcohol
类别
资金
- Sparta Biomedical
This article introduces a hydrogel with a higher strength than cartilage and its fixation method. The hydrogel achieves strength enhancement through reinforced crystallization of polyvinyl alcohol with bacterial cellulose. With higher wear resistance than cartilage, this hydrogel can be used for repairing damaged joints.
Key hurdles for replacing damaged cartilage with an equivalent synthetic construct are the development of a hydrogel with a strength that exceeds that of cartilage and fixation of this hydrogel onto the surface of an articulating joint. This article describes the first hydrogel with a tensile and compressive strength (51 and 98 MPa) that exceeds those of cartilage (40 and 59 MPa), and the first attachment of a hydrogel to a metal backing with a shear strength (2.0 MPa) that exceeds that of cartilage on bone (1.2 MPa). The hydrogel strength is achieved through reinforcement of crystallized polyvinyl alcohol with bacterial cellulose. The high attachment strength is achieved by securing freeze-dried bacterial cellulose to a metal backing with an adhesive and a shape memory alloy clamp prior to infiltration and crystallization of the polyvinyl alcohol. The bacterial cellulose-reinforced polyvinyl alcohol is three times more wear resistant than cartilage over one million cycles and exhibits the same coefficient of friction. These advances in hydrogel strength and attachment enable the creation of a hydrogel-based implant for durable resurfacing of damaged articulating joints.
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