4.7 Review

Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment

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Summary: Cancer immunotherapy has shown great progress in advanced-stage malignancies, but low response rates and immunosuppressive tumor microenvironments limit its effectiveness. Photodynamic therapy (PDT) can induce immunogenic cell death and enhance immune responses. Recent nanomedicine-based strategies have improved the efficiency of PDT and immunotherapy, and synergistic nanotherapeutics have been used to amplify immune responses. Challenges and future expectations in PDT-driven cancer immunotherapy are discussed.

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Summary: The near infrared-driven PDT platform based on photosynthetic cyanobacterial cells hybridized with photosensitizer rose bengal (RB)-loaded upconversion nanoparticles, named as UR-Cyan cells, offers enhanced and sustainable PDT efficacy against tumor cells/tissues by promoting both oxygen production and singlet oxygen generation. This design provides a practical approach to overcome the hypoxic burden of PDT operations with excellent biocompatibility and clinical promises.

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Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia

Haoran Wang et al.

Summary: A novel light-controlled sustainable PDT was developed in this study, utilizing photosynthetic microorganisms to produce oxygen and perfluorocarbon to enrich oxygen for sustained supply. This method not only avoided local hypoxia but also promoted dendritic cell activation and enhanced antitumor immune effects.

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Summary: A new immunotherapy approach combining innate immune activator and photodynamic therapy reagent has shown promising results in treating colon cancer, effectively inhibiting tumor growth, promoting immune cell infiltration, and enhancing cytotoxicity of immune cells. This approach may serve as an effective and safe platform for combinatory use with nano-herb medicine and PDT, providing a new therapy option for colon cancer treatment.

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Phthalocyanine-based photosensitizers combined with anti-PD-L1 for highly efficient photodynamic immunotherapy

Bi-Yuan Zheng et al.

Summary: Combining PDT caused by different-charged ZnPcs with anti-PD-L1 antibody has shown significant antitumor effects, with the cationic compound 2 exhibiting the highest synergistic antitumor effect with ICB and resulting in the most significant increase of CD8(+) T cells. This study suggests that mono-cationic ZnPc 2 is a highly promising photosensitizer specifically for PDT combined with immunotherapy, efficiently inhibiting tumor recurrence.

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Bioorthogonal Pretargeting Strategy for Anchoring Activatable Photosensitizers on Plasma Membranes for Effective Photodynamic Therapy

Ruili Wei et al.

Summary: The development of novel activatable photosensitizers with plasma membrane targeting ability is crucial for smart photodynamic therapy (PDT). This study combines a tumor acidity-activatable photosensitizer with a two-step bioorthogonal pretargeting strategy, effectively anchoring photosensitizers to the plasma membrane for enhanced therapeutic efficacy in anticancer therapy. The activation and click reaction-based localization of photosensitizers on tumor cells surface result in cytotoxic reactive oxygen species-induced cell membrane damage and apoptosis upon laser irradiation.

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Guoming Huang et al.

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A Photosensitive Polymeric Carrier with a Renewable Singlet Oxygen Reservoir Regulated by Two NIR Beams for Enhanced Antitumor Phototherapy

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Daoming Zhu et al.

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