Fluidity-Guided Assembly of Au@Pt on Liposomes as a Catalase-Powered Nanomotor for Effective Cell Uptake in Cancer Cells and Plant Leaves

The fluidity of the liposomes is essential to nanoparticle-membrane interactions. We herein report a liposomal nanomotor system by controlling the self-assembly behavior of gold core-platinum shell nanoparticles (Au@Pt) on liposomes. Au@Pt can aggregate immediately on fluid-phase dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes, forming an uneven distribution. By control of the lipid phase and fluidity, either using pure 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) above its phase transition temperature or adding cholesterol as an adjuvant to DPPC lipids, we precisely control the assembly of Au@Pt on liposomes. Au@Pt maintained high catalase-like activity on the liposomal surface, promoting the decomposition of H2O2 and the movement of the liposomal nanomotors. Finally, we demonstrate that liposomal nanomotors are biocompatible and they can speed up the cellular uptake in mammalian HepG2 cancer cells and Nicotiana tabacum (Nb) plant leaves. This liposomal nanomotor system is expected to be further investigated in biomedicine and plant nanotechnology.

Automated summary

In this study, a liposomal nanomotor system was developed by controlling the self-assembly behavior of gold core-platinum shell nanoparticles on liposomes. This system showed high catalase-like activity and promoted the decomposition of H2O2, leading to enhanced cellular uptake in cancer cells and plant leaves. These findings are important for biomedical and plant nanotechnology research.