期刊
ACS NANO
卷 16, 期 7, 页码 10890-10903出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c03188
关键词
Bio-Integrated Electronics; Functional Endoscopy; Irreversible Electroporation; Radio Frequency Ablation; Silicon Carbide; Thermal Ablation
类别
资金
- Australian Research Council (ARC) [DE200100238]
- Griffith IMPACT Spotlight
- MME RIS grant
- Griffith Postdoctoral Fellowship
- JST-ERATO [JPMJER2003]
- UNSW Faculty of Engineering Open -Access Publishing Award
- UNSW MME startup grant
- Australian Research Council [DE200100238] Funding Source: Australian Research Council
The integration of micro- and nanoelectronics into or onto biomedical devices has the potential to revolutionize the diagnostics and treatments of various diseases. This study introduces transparent and stable cubic silicon carbide (3C-SiC)-based bioelectronic systems that can be integrated onto endoscopes, enabling tissue ablation and peripheral nerve stimulation. Experimental studies demonstrated the effectiveness and efficiency of the system for lesion removal and neural disorder therapy through electrical excitation.
The integration of micro-and nanoelectronics into or onto biomedical devices can facilitate advanced diagnostics and treatments of digestive disorders, cardiovascular diseases, and cancers. Recent developments in gastrointestinal endoscopy and balloon catheter technologies introduce promising paths for minimally invasive surgeries to treat these diseases. However, current therapeutic endoscopy systems fail to meet requirements in multifunctionality, biocompatibility, and safety, particularly when integrated with bioelectronic devices. Here, we report materials, device designs, and assembly schemes for transparent and stable cubic silicon carbide (3C-SiC)-based bioelectronic systems that facilitate tissue ablation, with the capability for integration onto the tips of endoscopes. The excellent optical transparency of SiC-on-glass (SoG) allows for direct observation of areas of interest, with superior electronic functionalities that enable multiple biological sensing and stimulation capabilities to assist in electrical-based ablation procedures. Experimental studies on phantom, vegetable, and animal tissues demonstrated relatively short treatment times and low electric field required for effective lesion removal using our SoG bioelectronic system. In vivo experiments on an animal model were conducted to explore the versatility of SoG electrodes for peripheral nerve stimulation, showing an exciting possibility for the therapy of neural disorders through electrical excitation. The multifunctional features of SoG integrated devices indicate their high potential for minimally invasive, cost-effective, and outcome-enhanced surgical tools, across a wide range of biomedical applications.
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