Glucose-Activated Nanoconfinement Supramolecular Cascade Reaction in Situ for Diabetic Wound Healing

Supramolecular nanofunctional materials have attracted increasing attention from scientific researchers due to their advantages in biomedicine. Herein, we construct a nanosupramolecular cascade reactor through the cooperative interaction of multiple noncovalent bonds, which include chitosan, sulfobutylether-beta-cyclodextrin, ferrous ions, and glucose oxidase. Under the activation of glucose, hydroxyl radicals generated from the nanoconfinement supramolecular cascade reaction process are able to initiate the radical polymerization process of vinyl monomers to form hydrogel network structures while inhibiting resistant bacterial infection. The results of the diabetic wound experiment confirmed the capacity of the glucose-activated nanoconfinement supramolecular cascade reaction in situ for potent antimicrobial efficacy and wound protection. This strategy of two birds with one stone provides a convenient method for the application of supramolecular nanomaterial in the field of biomedicine.

Automated summary

This study constructed a nanosupramolecular cascade reactor through the cooperative interaction of multiple noncovalent bonds. The reactor generates hydroxyl radicals under glucose activation, forming hydrogel network structures and inhibiting resistant bacterial infection. The experimental results confirmed the importance of this method in the treatment of diabetic wounds.