4.8 Article

Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria

期刊

ACS NANO
卷 -, 期 -, 页码 -

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c02269

关键词

multi-drug-resistant bacteria; gold nanoantibiotics; surface modification; structure-activity relationship; biosafety; wound dressing; implantable devices; clinical translation

资金

  1. National Key R&D Program of China [2018YFA0902600]
  2. Guangdong Provincial Key Laboratory of Advanced Biomaterials [2022B1212010003]
  3. Shenzhen Science and Technology Program [KQTD20190929172743294]
  4. Shenzhen Key Laboratory of Smart Healthcare Engineering [ZDSYS20200811144003009]
  5. Tencent Foundation through the XPLORER PRIZE

向作者/读者索取更多资源

Antibiotic resistance is a serious threat to human health and nanotechnology, particularly gold nanomaterials, provides an effective solution with their excellent antibacterial efficacy and biosafety, making them potential alternatives to traditional antibiotics.
Antibiotic resistance has become a serious threat to human health due to the overuse of antibiotics. Different antibiotics are being developed to treat resistant bacteria, but the development cycle of antibiotics is hard to keep up with the high incidence of antibiotic resistance. Recent advances in antimicrobial nanomaterials have made nanotechnology a powerful solution to this dilemma. Among these nanomaterials, gold nanomaterials have excellent antibacterial efficacy and biosafety, making them alternatives to antibiotics. This review presents strategies that use gold nanomaterials to combat drug-resistant bacteria. We focus on the influence of physicochemical factors such as surface chemistry, size, and shape of gold nanomaterials on their antimicrobial properties and describe the antimicrobial applications of gold nanomaterials in medical devices. Finally, the existing challenges and future directions are discussed.

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