Tough Wet Adhesion of Hydrogen-Bond-Based Hydrogel with On- Demand Debonding and Efficient Hemostasis

Hydrogels have been widely used in wet tissues. However, the insufficient adhesion of hydrogels for wound hemostasis remains a grand challenge. Herein, a facile yet effective strategy is developed to fabricate tough wet adhesion of hydrogen-bond-based hydrogel (PAAcVI hydrogel) using copolymerization of acrylic acid and 1-vinylimidazole in dimethyl sulfoxide followed by solvent exchange with water. The PAAcVI hydrogel shows equally robust adhesion (> 400 J m(-2)) to both wet and dry tissues. Moreover, the PAAcVI hydrogel also exhibits strong long-term stable adhesion underwater and in various wet environments. Meanwhile, the adhesion of PAAcVI hydrogel can be adjusted through Zn2+-ion-mediated on-demand debonding, which makes it easy to peel off from the tissue reducing pain during dressing removal and avoiding secondary injury. The PAAcVI hydrogel displays efficient hemostasis in the mice-tail docking model and mice-liver bleeding model. This hydrogen-bond-based hydrogel shows tough wet adhesion, and its adhesion is controllable, demonstrating its promising application in moisture-resistant adhesives, medical adhesives, and hemostatic materials.

Automated summary

In this study, a hydrogen-bond-based hydrogel with tough wet adhesion was developed. The adhesion of the hydrogel can be adjusted by Zn2+ ions. The hydrogel exhibits strong adhesion to both wet and dry tissues and maintains stable adhesion in underwater and various wet environments. Additionally, the hydrogel shows efficient hemostasis in mouse models.