期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 33, 页码 37291-37300出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c06306
关键词
single-cell analysis; electrochemical monitoring; in situ self-assembly; miRNA delivery; tumor imaging and inhibition
资金
- National Natural Science Foundation of China [82061148012, 82027806, 21974019, 92061121]
- National High-tech RD Program
- National Key Research & Development Program of China [2017YFA0205301]
- Primary Research & Development Plan of Jiangsu Province [BE2019716]
- ISF-NSFC Joint Research Program [3258/20]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_0142]
With the deepening of cancer clinical research, miRNAs provide new ideas for molecular diagnosis and treatment of tumors. Improving the molecular delivery efficiency of miRNA is the key to the success of miRNA therapy. The study proposes a self-assembly diagnosis and treatment technology based on metal precursor-mediated tumor microenvironmental response, which can achieve accurate targeting and cargo delivery.
With the deepening of cancer clinical research, miRNAs provide new ideas for molecular diagnosis and treatment of tumors. Improving the molecular delivery efficiency of miRNA is the key to the success of miRNA therapy. We have established self -assembly diagnosis and treatment technologies that can be used to achieve accurate targeting and cargo delivery at the cellular level. This technology builds a miRNA (let -7a) delivery system based on metal precursor [Au(III) and Fe(II)]-mediated tumor microenvironmental response to realize the self-assembly of Au&Fe-miRNA complexes for precise real-time imaging of tumor cells and targeted therapy. To accurately measure the changes in reactive oxygen species during complex formation in real time at the single-cell level, we employed small-size nanoscale devices as analytical tools. This study proposes an electrochemical sensor based on carbon fiber electrodes for ultraprecise and multiple monitoring of metal-ion-mediated miRNA delivery systems, precisely realizing targeted tracking of tumors and effective intervention inhibition.
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