期刊
AAPS JOURNAL
卷 24, 期 5, 页码 -出版社
SPRINGER
DOI: 10.1208/s12248-022-00721-1
关键词
dissolution; in vitro; membrane transport; oral absorption; passive diffusion
资金
- Genentech Inc.
- College of Pharmacy, University of Minnesota
The purpose of this study was to develop and validate a tool for simultaneous dissolution and absorption testing of oral drug formulations, called the artificial gut simulator (AGS). The AGS was optimized to simulate physiological gastric emptying and drug absorption using a high aqueous solubility model compound, caffeine. This study provides a framework for establishing in vitro/in vivo correlation for high-permeability supersaturating drug formulations.
The purpose of this study was to develop and validate a simultaneous dissolution and absorption testing tool, the artificial gut simulator (AGS), for oral drug formulations. The AGS was constructed using hollow fibers and housed in a 3-mL UV spectrophotometric cuvette that provided a large surface area-to-volume ratio to simulate absorption at a physiological rate. A quasi-steady-state model describing absorption was developed and validated using a high aqueous solubility, BCS-I model compound, caffeine. This model was used to optimize the AGS operating parameters to simulate physiological gastric emptying and caffeine absorption, which was further input into a one-compartment pharmacokinetic (PK) model. The in vivo caffeine plasma concentration-time profiles matched those predicted by the PK model with in vitro input from the AGS. This work provides a framework for establishing an in vitro/in vivo correlation with high-permeability, BCS-II supersaturating drug formulations, which will be explored in the future studies.
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