期刊
JOURNAL OF CLINICAL LABORATORY ANALYSIS
卷 30, 期 5, 页码 649-655出版社
WILEY
DOI: 10.1002/jcla.21917
关键词
TNF-alpha; IL-10; salivary cytokine level; metabolic syndrome; periodontitis
Background: Metabolic Syndrome (MS) and chronic oral condition (periodontitis [PD]) are state of inflammation. The study was conducted to determine alterations in serum and salivary cytokines level in MS and/or chronic PD in the North Indian population. Materials and Methods: This cross-sectional study carried out in northern part of India. The study subjects of similar ethnicity were recruited according to International Diabetes Federation (IDF) criteria for MS, while chronic PD was diagnosed on the basis of packet depth and clinical attachment level. ELISA method was employed to assess cytokine level. All subjects were divided in four groups Gr A (MS + PD), B (MS), C (PD), and a control Gr D. Results: The serum and salivary tumor necrosis factor alpha (TNF-alpha) level in Gr A, B, and C was significantly higher than Gr D (P < 0.05). Serum interleukin-10 (IL-10) level in Gr A, B, and C was lower than Gr D (P < 0.05), but this difference was not significant between Gr C and Gr D. Serum IL-10 level in Gr A was significantly lower than Gr C (P < 0.05). Salivary IL-10 level was not significantly altered in any group. Conclusions: Proinflammatory marker TNF-alpha has correlation with clinical parameters in patients of MS having PD. The study suggests level of salivary TNF-alpha may be utilized as a surrogate marker of MS and PD. (C) 2016 Wiley Periodicals, Inc.
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