期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 126, 期 3, 页码 833-836出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI86650
关键词
-
The central role of the transcriptional template of the hepatitis B virus (HBV), covalently closed circular DNA (cccDNA), has been difficult to study in patients with chronic hepatitis B (CHB) infection. In this issue of the JCI, Zhang and colleagues reveal a mosaic distribution of viral antigens and nucleic acids and a mismatch between HBV cccDNA, RNA, and expression of the hepatitis B surface antigen (HBsAg). These unusual patterns varied over the natural history of CHB, prompting the authors to propose a new three stage model of the HBV life cycle at the single-cell level.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据