期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 101, 期 5, 页码 2218-2225出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2016-1076
关键词
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资金
- National Natural Science Foundation of China [81270885, 81070677, 815070726]
- Shanghai Jiaotong University School of Medicine
- Ministry of Science and Technology in China [2012CB524906]
- Science and Technology Commission of Shanghai Municipality [14495810700]
Context: Epidemiologic studies have indicated that early life nutrition influences later risk of obesity, type 2 diabetes, and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) is also considered a metabolic disease. Objective: The aim was to explore the association between adult NAFLD and fetal or childhood exposure to Great Chinese Famine between 1959 and 1962 during fetal and childhood period. Design and setting: In total, 5306 subjects from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors study were divided into a fetal-exposed (1959-1962), childhood exposed (1949-1958), adolescence/young adult-exposed (1921-1948), and nonexposed (19631974, reference) group. Main outcome measure: The degrees of steatosis of NAFLD were determined by ultrasonography. Results: The prevalences of NAFLD in the nonexposed (1963-1974), fetal-exposed, and childhood exposed participants were 55.9%, 55.8%, and 55.4% in men and 33.0%, 46.3%, and 51.7% in women, respectively. Compared with those nonexposed, fetal- and childhood-exposed women but not men had a significantly higher prevalence of moderate-severe steatosis (P < .05). A significant association existed in women between increased alanine aminotransferase and both fetal and childhood exposure to famine, after adjusting for age, rural/urban residence, economic status, body mass index, diabetes, dyslipidemia, and hypertension (both P < .05). Famine exposure during the fetal period (odds ratio 1.77, 95% confidence interval 1.22, 2.57) and childhood (odds ratio 1.82, 95% confidence interval 1.35, 2.46) was associated with an increased prevalence of moderate severe NAFLD in women in the above fully adjusted model. Conclusions: Exposure to the Great Famine in early life had sex-specific association with moderate severe NAFLD. This indicates that malnutrition in early life may influence the development of adult NAFLD; thus pregnant women and their infants and children may require the highest priority in obtaining nutritional relief.
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