期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 101, 期 11, 页码 3939-3951出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2016-1669
关键词
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资金
- Medical Research Council [G0701757]
- Wellcome Trust [084840]
- National Institute for Health Research (NIHR Research Methods Programme) [NIHR-RMFI-2014-05-8]
- United Kingdom Medical Research Council (MRC)
- MRC/CSO Social & Public Health Sciences Unit, University of Glasgow [MC_UU_12017-11]
- MRC [G0701757, MC_UU_12017/11] Funding Source: UKRI
- Chief Scientist Office [SPHSU11] Funding Source: researchfish
- Medical Research Council [G0701757, MC_UU_12017/11] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10078, NF-SI-0508-10244, NIHR-RMFI-2014-05-28-101, CL-2010-18-010] Funding Source: researchfish
Context: Salivary T (Sal-T) measurement by liquid chromatography-tandem mass spectroscopy resents the opportunity to examine health correlates of Sal-Tin a large-scale population survey. Objective: This study sought to examine associations between Sal-T and health-related factors in men and women age 18-74 years. Design and Setting: Morning saliva samples were obtained from participants in a cross-sectional probability-sample survey of the general British population (Natsal-3). Self-reported health and lifestyle questions were administered as part of a wider sexual health interview. Participants: Study participants included 1599 men and 2123 women. Methods: Sal-T was measured using liquid chromatography-tandem mass spectroscopy. Linear regression was used to examine associations between health factors and mean Sal-T. Results: In men, mean Sal-T was associated with a range of health factors after age adjustment, and showed a strong independent negative association with body mass index (BMI) in multivariable analysis. Men reporting cardiovascular disease or currently taking medication for depression had lower age-adjusted Sal-T, although there was no association with cardiovascular disease after adjustment for BMI. The decline in Sal-T with increasing age remained after adjustment for health-related factors. In women, Sal-T declined with increasing age; however, there were no age-independent associations with health-related factors or specific heath conditions with the exception of higher Sal-T in smokers. Conclusions: Sal-T levels were associated, independently of age, with a range of self-reported health markers, particularly BMI, in men but not women. The findings support the view that there is an age-related decline in Sal-T in men and women, which cannot be explained by an increase in ill health. Our results demonstrate the potential of Sal-T as a convenient measure of tissue androgen exposure for population research.
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