期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 101, 期 7, 页码 2802-2809出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2015-4262
关键词
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资金
- National Institutes of Health (NIH), Department of Health and Uhlman Services, through the National Institute on Aging
- National Institute of Nursing Research
- NIH Office of Research on Women's Health [NR004061, AG012505, AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, AG012495]
- National Institute on Aging [P30-AG028748, 5P30AG028748, 5U01AG012539-22]
- NIH/National Center for Advancing Translational Sciences UCLA Clinical and Translational Science Institute [UL1TR000124]
- NIH [5R01AG033067]
- UCLA Specialty Training and Advanced Research Program
Context: Bone gain vs loss across the skeleton loss depends on the balance between total bone formation and total bone resorption. Objective: The objective of the study was to determine whether resorption and formation markers can be combined to gauge net bone formation across the skeleton. Design: The study included a cohort followed up across menopause transition (Study of Women's Health Across the Nation). Setting and Participants: Community-dwelling women, 42-52 years old, premenopausal or early perimenopausal at baseline, participated in the study. Outcome: The study included the following measures: 1) bone balance index (BBI) created by estimating the relationship between resorption (urinary N-telopeptide) and formation (osteocalcin) markers when the total formation equals the total resorption in 685 women with stable bone mineral density (BMD) (>5 y beforethe final menstrual period [FMP]) and applying this relationship to measured bone turnover markers in 216 women beginning to lose bone y from FMP); and 2) annualized percentage declines over the following 3-4 years in the lumbar spine (LS) and femoral neck (FN) BMD. Results: Adjusted for covariates, the BBI was greater (more favorable) in women with a greater body mass index (P =.03) and lower (less favorable) in women closer to the FMP (P = .007). Each SD decrement in BBI was associated with 0.27%/y faster LS BMD decline (P = 0.0 4) and a 38% higher odds of faster-than-average loss of LS bone mass (P = .008, c-statistic 0.76). BBI was not associated with decline in FN BMD. Urinary N-telopeptide alone was not associated with either LS or FN BMD decline. Conclusions: An index that quantifies net bone formation vs resorption can be created from bone turnover markers and may help identify individuals at high risk for LS bone loss.
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