期刊
CANCER RESEARCH
卷 75, 期 4, 页码 624-627出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-14-3081
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资金
- American Cancer Society for a Lee National Denim Day Postdoctoral Fellowship Award [PF-t3-367-01-CDD]
- Ruth L. Kirchstein National Research Service Award [NIH/NCI T32 CA009523]
- Era of Hope Scholar Award from Breast Cancer Research Program of the Department of Defense [W81XWH-10-1-0822]
- NIH Director's New Innovator Award [DP2-OD004265]
- Burroughs Wellcome Fund Career Award in the Biomedical Sciences
GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3's roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer. Our recent investigation of the regulation of GOLPH3 revealed a surprising response by the Golgi upon DNA damage that is mediated by DNA-PK and GOLPH3. These results provide new insight into the DNA damage response with important implications for understanding the cellular response to standard cancer therapeutic agents. (C)2015 AACR.
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