期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 101, 期 3, 页码 1098-1103出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2015-3928
关键词
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资金
- National Cancer Research Institute's Thyroid Cancer Subgroup
- National Cancer Research Network
- University of California Davis
- V Foundation for Cancer Research
- National Institute On Aging (UC Davis Latino Aging Research Resource Center) [P30AG043097]
- National Cancer Institute (Paul Calabresi Career Development Award for Clinical Oncology K12 at UC Davis) of the National Institutes of Health [K12CA138464]
- FP7 CHIBCHA Consortium
- Wellcome Trust [075491/Z/04]
- Cancer Research UK
- European Commission
- Programas Doctorales Becas COLCIENCIAS
- Research Office from University of Tolima [400111, 360113]
- Medical Research Council [G1001799, MR/N01104X/1] Funding Source: researchfish
- MRC [G1001799, MR/N01104X/1] Funding Source: UKRI
Context: A recent study reported the nonsynonymous G534E (rs7080536, allele A) variant in the HABP2 gene as causal in familial nonmedullary thyroid cancer (NMTC). Objective: The objective of this study was to evaluate the causality of HABP2 G534E in the TCUKIN study, a multicenter population-based study of NMTC cases from the British Isles. Design and Setting: A case-control analysis of rs7080536 genotypes was performed using 2105 TCUKIN cases and 5172 UK controls. Participants: Cases comprised 2105 NMTC cases. Patient subgroups with papillary (n = 1056), follicular (n = 691), and Hurthlee cell (n = 86) thyroid cancer cases were studied separately. Controls comprised 5172 individuals from the 1958 Birth Cohort and the National Blood Donor Service study. The controls had previously been genotyped using genome-wide single nucleotide polymorphism arrays by the Wellcome Trust Case Control Consortium study. Outcome Measures: Association between HABP2 G534E (rs7080536A) and NMTC risk was evaluated using logistic regression. Results: The frequency of the HABP2 G534E was 4.2% in cases and 4.6% in controls. We did not detect an association between this variant and NMT Crisk (odds ratio [OR] = 0.896; 95% confidence interval, 0.746-1.071; P = .233). We also failed to detect an association between the HABP2 G534E and cases with papillary (1056 cases; G534E frequency = 3.5%; OR = 0.74; P = .017), follicular (691 cases; G534E frequency = 4.7%; OR = 1.00; P = 1.000), or Hurthle cell (86 cases; G534E frequency = 6.3%; OR = 1.40; P = .279) histology. Conclusions: We found that HABP2 G534E is a low-to-moderate frequency variant in the British Isles and failed to detect an association with NMTC risk, independent of histological type. Hence, our study does not implicate HABP2 G534E or a correlated polymorphism in familial NMTC, and additional data are required before using this variant in NMTC risk assessment.
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