期刊
PHARMANUTRITION
卷 20, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.phanu.2022.100296
关键词
Green tea polyphenols; Cardiovascular disease; Inter-individual variability; Genetic polymorphism; Phyto-genomic
类别
资金
- TIFAC CORE in Herbal Drugs, JSS Col-lege of Pharmacy, Ooty [45/43/2018/MP/BMS/dt]
- JSS Academy of Higher Education and Research
- Indian Council of Medical Research ICMR
This review critically appraises the various reported mechanisms and challenges of green tea polyphenols in modulating cardiometabolic health, and highlights the importance of personalizing the use of green tea based on individual gene polymorphisms.
Cardiovascular disease is a chronic multifactorial health complication that is either directly or indirectly associated with pathophysiological mechanisms, including pro-oxidation, pro-inflammation, vascular and endothelial dysfunction, impaired platelet function, thrombosis, and others. The therapeutic options to circumvent cardiovascular complications include several phytomedicines, including green tea polyphenols. However, while many experimental and clinical studies report distinct mechanisms by which the polyphenols of green tea elicit a beneficial role in cardiometabolic health, the translation and applications of green tea polyphenols in clinics have yet to gain their optimal use on the broader population. This review critically appraises the various reported mechanisms of green tea polyphenols in modulating cardio-metabolic health and associated phyto-genomic challenges. Further, our review highlights the probability of gene polymorphic associated therapeutic variations in individuals using green tea for cardio-metabolic effects and the necessity to personalize green tea for clinical use, thereby improvising the risk-benefit ratio.
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