期刊
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷 1008, 期 -, 页码 225-233出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2015.11.053
关键词
Molecularly imprinted polymers; HPLC; Natural products; Dencichine; Panax notoginseng
资金
- Natural Science Foundation of Shandong Province [ZR2015BQ005]
Specific molecularly imprinted polymers for dencichine were developed for the first time in this study by the bulk polymerization using phenylpyruvic acid and in-tyrosine as multi-templates. The photographs confirmed that molecularly imprinted polymers prepared using N,N'-methylene diacrylamide as crosslinker and glycol dimethyl ether as porogen displayed excellent hydrophilicity. Selectivity, adsorption isotherm and adsorption kinetics were investigated. The sample loading-washing-eluting solvent was optimized to evaluate the property of molecularly imprinted solid phase extract. Compared with LC/WCX-SPE, water-compatible molecularly imprinted solid phase extraction displayed more excellent specific adsorption performance. The extracted dencichine from Panax notoginseng with the purity of 98.5% and the average recovery of 85.6% (n = 3) was obtained. (C) 2015 Elsevier B.V. All rights reserved.
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