期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1467, 期 -, 页码 2-18出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2016.07.040
关键词
High-efficiency chiral separations; High-throughput chromatography; Superficially porous particles; HPLC and SFC enantiomeric separations; Ultrafast separations; Instrument optimizations
资金
- Robert A. Welch Foundation [Y-0026]
The need for improved liquid chromatographic chiral separations has led to the advancement of chiral screening techniques as well as the development of new, high efficiency chiral separation methods and stationary phases. This review covers these advancements, which primarily occurred over the last 15 years. High throughput techniques include multi-column screening units, multiple injection sequences, and fast gradient SFC screening. New separation methods and column technologies that aim at high efficiency chiral separations include the use of achiral UHPLC (i.e. sub-2 mu m) columns for separating derivatized chiral analytes or using chiral additives in the run buffer, UHPLC chiral stationary phases, and. superficially porous particle based chiral stationary phases. Finally, the enhancement of chiral separations through these new technologies requires that certain instrumental considerations be made. Future directions in continuing to improve chiral separations are also discussed. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据