期刊
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
卷 57, 期 12, 页码 1455-1462出版社
WILEY-BLACKWELL
DOI: 10.1111/jcpp.12602
关键词
Congenital adrenal hyperplasia; fetal testosterone; prenatal testosterone exposure; autism; autistic traits; extreme male brain
资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health [R01HD024542]
- March of Dimes
BackgroundThere is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. MethodsA parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4-11years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3-5years. ResultsFindings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample. ConclusionsThese studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits. Read the Commentary on this article at doi:
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