期刊
JOURNAL OF CHEMOTHERAPY
卷 28, 期 6, 页码 476-481出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1120009X.2016.1139335
关键词
Acinetobacter baumannii; Pulsed-field gel electrophoresis; Resistance; Transmission mechanism
The aim of this study was to analyse the resistance and epidemiological data of 117 Acinetobacter baumannii isolates from Southwest Hospital, Chongqing, China. Except for polymyxin B, tigecycline, minocycline, cefoperazone/sulbactam, amikacin and levofloxacin, the resistance rates of other antimicrobial agents were above 90%. All the clinical isolates had the bla(OXA-51) gene and 114 isolates had the bla(OXA-23) gene. Forty-nine isolates were found to contain the bla(IMP-4) gene. PFGE data showed that 117 isolates were divided into 25 groups. Sixty-three (53.85%) were found to carry the class 1 integron, and the sequence analysis of the class 1 integron internal variable regions - five types, one of which had the bla(IMP-4) gene. For the bla(IMP-4) positive strain without class 1 integron, we found the flanking sequence had the TnpA gene. The result suggested that the resistance gene was widely distributed in our hospital; moreover, the modes of presence and transmission are different and complicated. The results of our study can improve the infection empirical treatment method and infection control programme.
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