Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage

Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH. Materials & methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH. Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume. Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH. Plain language summary Hemorrhagic stroke, caused by the leakage of blood from blood vessels to the brain, is a life-threatening condition that reduces the quality of life of a large number of patients worldwide without effective treatments. Here, we induced a severe hemorrhagic stroke in rats to study the effects of a treatment using mesenchymal stromal cells, stem cells obtained from the umbilical cord tissue capable of producing protective molecules for the brain. The treatment; however, did not improve some aspects of the disease, such as the motor ability and the size of the brain lesion, indicating that further studies are still necessary.

Automated summary

Intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) shows limited efficacy in the treatment of intracerebral hemorrhage (ICH), especially in severe cases. Hyperacute treatment with hUC-MSC does not significantly improve the survival rate, motor function, or residual hematoma volume in severe ICH. Further optimization of hUC-MSC-based therapies is needed.