期刊
JOURNAL OF GASTROINTESTINAL CANCER
卷 54, 期 1, 页码 304-308出版社
SPRINGER
DOI: 10.1007/s12029-022-00808-0
关键词
Monomorphic epitheliotropic intestinal T cell lymphoma; T cell lymphomas; Gastrointestinal lymphomas; Extranodal lymphomas; PEG-asparaginase
This case report provides new evidence on the effectiveness of PEG-asparaginase therapy in MEITL patients. However, the high toxicity of this treatment should be taken into consideration.
Purpose MEITL is a very rare and highly aggressive peripheral T cell lymphoma with poor prognosis and for which there is no standard treatment. Treatment options for patients patients with relapsed/refractory disease are scarce and the choice of an appropriate rescue still represents an unmet need. Methods Here, we report the case of a 65-year-old woman affected by MEITL, progressing after initial treatment with an anthracycline-based chemotherapy and surgery, who received single-agent PEG-asparaginase salvage therapy at our institution. Results PEG-asparaginase single-agent rescue proved to be rapidly effective in controlling the disease and its associated paraneoplastic features. Nevertheless, toxicity was high and the patient died due to a treatment-related complication. Conclusion The case we described brings new evidences on the effectiveness of PEG-asparaginase therapy in MEITL patients. Whether PEG-asparaginase should be included in the treatment course of MEITL patients could be the subject of future studies.
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