4.1 Review

Subcutaneous surgical rat models for the evaluation of decellularised heart valve immunogenicity: A systematic review

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Models of immunogenicity in preclinical assessment of tissue engineered heart valves

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Summary: Tissue engineered heart valves offer a potential alternative to traditional valve prostheses, but predicting their in vivo performance is challenging. Understanding the short and long term immune reactions is crucial for bringing these prostheses to market, and researchers need to utilize a variety of models to fully elucidate the host's impact on the graft.

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