期刊
DATA IN BRIEF
卷 42, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.dib.2022.108279
关键词
Functional connectivity; Resting state; Magnetic Resonance Imaging; MRI; Medetomidine; Electrical stimulation
资金
- Motor Accident Insurance Commission (MAIC), Queensland Government, Australia [20140 00857]
This study utilized nine 8C57Bl6 mice for MRI scanning, involving drug injections at different doses and electrical stimulation. The dataset includes preprocessed fMRI images and various correction steps.
Nine 8 C57Bl6 mice (9 +/- 0.5 months) were utilised for this dataset. Each animal was scanned twice on a 9.4T Bruker Magnetic Resonance Imaging (MRI) scanner using a cryogenically cooled coil with 0.1 mg/kg body weight/h (low) or 0.3 mg/kg body weight/h (high) medetomidine doses; 0.5% isoflurane was used in conjunction with both doses. The scans were one week apart, and the first session's dose was decided randomly. In each session, the animal had a pre-stimulation resting-state functional Magnetic Resonance Imaging (rs-fMRI) scan followed by 10 min where mild, constant electrical stimulation to the forepaw was applied, and a post-stimulation rs-fMRI scan. Each fMRI scan lasted 10 min, and there was 5 min break between fMRI scans. The dataset included, for each animal, a pair of forwardphase and reverse-phase gradient echo Echo-Planar-Imaging (EPI) images for EPI distortion correction purpose and three (unprocessed) functional MRI images acquired using the same EPI sequence: prior, during, and post-stimulation. The MRI data was saved in compressed NIFTI format converted from Bruker DICOMs. The dataset also included the preprocessed functional MRI images, with the following preprocessing steps: slice-timing correction, temporal despiking, motion correction, distortion correction, band-pass filtration at 0.01-0.2 Hz, and spatial normalisation. This dataset adds to the publicly available collection of resting-state functional MRI in the mice and facilitates reproducibility and validation of functional imaging and its analysis. (C) 2022 The Authors. Published by Elsevier Inc.
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