期刊
PHYSIOLOGICAL REPORTS
卷 10, 期 8, 页码 -出版社
WILEY
DOI: 10.14814/phy2.15277
关键词
autonomic function; blood pressure; FSHD; heart rate variability; muscular dystrophy
类别
资金
- Friends of FSH Research
- National Institutes of Arthritis and Musculoskeletal and Skin Diseases [R01 AR055685]
- University of Minnesota's NIH Clinical and Translational Science Award [UL1TR002494]
- NIA T32 [T32AG029796]
- NIA K01 [AG064038-01A1]
Facioscapulohumeral muscular dystrophy (FSHD), a common form of muscular dystrophy, is caused by a genetic mutation. This study found that baroreflex sensitivity (BRS) is not reduced in FSHD patients, but an elevated heart rate may be due to low physical activity levels.
Facioscapulohumeral muscular dystrophy (FSHD), a common form of muscular dystrophy, is caused by a genetic mutation that alters DUX4 gene expression. This mutation contributes to significant skeletal muscle loss. Although it is suggested that cardiac muscle may be spared, people with FSHD have demonstrated autonomic dysregulation. It is unknown if baroreflex function, an important regulator of blood pressure (BP), is impaired in people with PSI ID. We examined if baroreflex sensitivity (BRS) is blunted in patients with FSHD. Thirty minutes of resting BP, heart rate, and cardiovagal BRS were measured in 13 patients with FSHD (age: 50 +/- 13 years, avg +/- SD) and 17 sex- and age-matched controls (age: 47 +/- 14 years, p > 0.05). People with FSHD were less active (Activity Metabolic Index, AMI) (FSHD: 24 +/- 30; controls: 222 +/- 175 kcal/day; p < 0.001) but had a similar body mass index compared with controls (FSHD: 27 +/- 4; controls: 27 +/- 4 kg/m(2): p > 0.05). BRSup (hypertensive response), BRSdown (hypotensive response), and total BRS were similar between groups (BRSup: FSHD: 12 +/- 8; controls: 12 +/- 5 ms/mmHg; BRSdown: FSHD: 10 +/- 4; controls: 13 +/- 6 ms/mmHg; BRS: FSHD: 14 +/- 9; controls: 13 +/- 6 ms/mmHg; p > 0.05). Mean arterial pressure was similar between groups (FSHD: 96 +/- 7; controls: 91 +/- 6mmHg). Individuals with FSHD had an elevated heart rate compared with controls (FSHD: 65 +/- 8; controls: 59 +/- 8 BPM; p = 0.03), but when co-varied for AMI, this relationship disappeared (p = 0.39). 'These findings suggest that BRS is not attenuated in people with FSHD, but an elevated heart rate may be due to low physical activity levels, a potential consequence of limited mobility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据