Solubilities of Three Flavonoids in Different Natural Deep Eutectic Solvents at T = (288.15 to 328.15) K

The solubilities of phloretin, phlorizin, and naringin dihydrochacone (naringin DC) respectively were determined in a ternary system made of natural deep eutectic solvents (NADES) at the temperature range from 288.15 to 328.15 K with an analytical method. Compared with the solubility of phloretin in water, there was a dramatic improvement in the solubility of phloretin in the selected NADES, especially in CCiH and CSH. The density and viscosity of four kinds of NADES choline chloride + glucose + H2O, choline chloride + citric acid + H2O, citric acid + glucose + H2O, and choline chloride + sucrose + H2O were studied in this work. The solubility data were correlated with Apelblat equation and lambda h equation. The fitted results showed that the models are capable of representing the data with high accuracy.