期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 37, 期 2, 页码 740-749出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X16645593
关键词
Alzheimer's disease; early-phase carbon-11 Pittsburgh Compound-B; early-phase [F-18]THK5317 positron emission tomography; 2-deoxy-2-[F-18]fluoro-D-glucose; simplified reference tissue model R-1
资金
- Swedish Research Council [05817]
- Swedish Foundation for Strategic Research (SSF)
- Karolinska Institutet Strategic Neuroscience program
- Stockholm County Council-Karolinska Institutet regional agreement on medical training and clinical research (ALF grant)
- Swedish Brain Power
- Swedish Brain Foundation
- Alzheimer Foundation in Sweden
- Dementia Association
- European Union [HEALTH-F2-2011-278850]
- Foundation for Old Servants, Karolinska Institutet's Foundation for Aging Research
- Gun and Bertil Stohne's Foundation
- Loo and Hans Osterman's Foundation
- Ahlen Foundation
- Wenner-Gren Foundation
For amyloid positron emission tomography tracers, the simplified reference tissue model derived ratio of influx rate in target relative to reference region (R-1) has been shown to serve as a marker of brain perfusion, and, due to the strong coupling between perfusion and metabolism, as a proxy for glucose metabolism. In the present study, 11 prodromal Alzheimer's disease and nine Alzheimer's disease dementia patients underwent [F-18]THK5317, carbon-11 Pittsburgh Compound-B ([C-11]PIB), and 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) positron emission tomography to assess the possible use of early-phase [F-18]THK5317 and R-1 as proxies for brain perfusion, and thus, for glucose metabolism. Discriminative performance (prodromal vs Alzheimer's disease dementia) of [F-18]THK5317 (early-phase SUVr and R-1) was compared with that of [C-11]PIB (early-phase SUVr and R-1) and [F-18]FDG. Strong positive correlations were found between [F-18]THK5317 (early-phase, R-1) and [F-18]FDG, particularly in frontal and temporoparietal regions. Differences in correlations between early-phase and R-1 ([F-18]THK5317 and [C-11]PIB) and [F-18]FDG, were not statistically significant, nor were differences in area under the curve values in the discriminative analysis. Our findings suggest that early-phase [F-18]THK5317 and R-1 provide information on brain perfusion, closely related to glucose metabolism. As such, a single positron emission tomography study with [F-18]THK5317 may provide information about both tau pathology and brain perfusion in Alzheimer's disease, with potential clinical applications.
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