期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 37, 期 3, 页码 951-966出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X16648710
关键词
ATP; brain development; brain slice; energy metabolism; lipids
资金
- Wellcome Trust [097265/Z/11/A, 099222/Z/12/Z]
- ERC (Advanced Investigator Award BRAINPOWER) [249670]
- Marie Curie Fellowship
- Wellcome Trust [097265/Z/11/A] Funding Source: Wellcome Trust
- Wellcome Trust [099222/Z/12/Z] Funding Source: researchfish
- European Research Council (ERC) [249670] Funding Source: European Research Council (ERC)
Energy use in the brain constrains its information processing power, but only about half the brain's energy consumption is directly related to information processing. Evidence for which non-signalling processes consume the rest of the brain's energy has been scarce. For the first time, we investigated the energy use of the brain's main non-signalling tasks with a single method. After blocking each non-signalling process, we measured oxygen level changes in juvenile rat brain slices with an oxygen-sensing microelectrode and calculated changes in oxygen consumption throughout the slice using a modified diffusion equation. We found that the turnover of the actin and microtubule cytoskeleton, followed by lipid synthesis, are significant energy drains, contributing 25%, 22% and 18%, respectively, to the rate of oxygen consumption. In contrast, protein synthesis is energetically inexpensive. We assess how these estimates of energy expenditure relate to brain energy use in vivo, and how they might differ in the mature brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据